Product image of Meriofert Set (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert Set

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert Set (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle‑stimulating hormone (FSH) and luteinising hormone (LH), the active ingredient in Meriofert Set, is a gonadotropin presented as an injectable solution for intramuscular and subcutaneous use. It treats infertility related to anovulation and is used in assisted reproductive technologies in women.
GNH India supplies Meriofert Set as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert Set is a gonadotropin used in fertility treatment pathways to stimulate ovarian function.

  • Anovulatory infertility: promotes follicular development and ovulation in women who do not ovulate spontaneously.
  • Controlled ovarian stimulation for assisted reproductive technologies: supports growth of multiple follicles for IVF cycles.
  • Ovulation induction in women undergoing IVF: enhances estradiol production and oocyte maturation to improve IVF outcomes.

How It Works

  • Follicle‑stimulating hormone and luteinising hormone in Meriofert Set bind to their respective receptors on ovarian granulosa and theca cells. Activation of these receptors triggers intracellular signaling cascades that stimulate follicular growth, estradiol synthesis, and the final maturation and release of the oocyte, facilitating ovulation and supporting assisted reproductive procedures.

Side Effects

Common Side Effects

  • Injection site reactions: pain, redness, or swelling at the injection site.
  • Mild abdominal discomfort or pelvic pressure.
  • Nausea or mild headache.
  • Mild ovarian hyperstimulation syndrome (OHSS) presenting as bloating.

Serious or Rare Side Effects

  • Severe OHSS: rapid weight gain, shortness of breath, or abdominal pain requiring medical attention.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Multiple pregnancy: increased risk of twins or higher-order gestations.

Precautions & Warnings

Precautions should be observed when using Meriofert Set to ensure patient safety.

  • Monitor ovarian response: perform ultrasound and estradiol measurements to adjust dosing.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Assess risk of ovarian hyperstimulation syndrome: use the lowest effective dose.
  • Use caution in patients with thromboembolic disorders: evaluate risk before treatment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions require careful management.

Major Interactions (Avoid)

  • GnRH agonists: may amplify ovarian response leading to severe OHSS.
  • Oral contraceptives: can suppress endogenous gonadotropins, reducing efficacy.
  • Anticoagulants: increased risk of bleeding with ovarian cyst rupture.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone therapy: may affect ovarian response.
  • Insulin sensitizers (e.g., metformin): may alter follicular development.
  • Corticosteroids: may modify hormone metabolism and response.

Frequently Asked Questions

Meriofert Set is an injectable gonadotropin containing follicle‑stimulating hormone and luteinising hormone. It is prescribed to treat infertility caused by anovulation, to support controlled ovarian stimulation in assisted reproductive technologies such as IVF, and to induce ovulation in women undergoing fertility treatment.

FSH and LH bind to specific receptors on ovarian granulosa and theca cells. This binding activates signaling pathways that promote follicular growth, estrogen production, and the final maturation and release of the oocyte, thereby facilitating ovulation and improving the chances of successful assisted reproduction.

The dose of Meriofert Set is individualized and determined by the prescribing fertility specialist based on the patient’s ovarian reserve, treatment protocol, and response monitoring. No fixed regimen is provided here; dosing decisions are made by qualified healthcare professionals.

Meriofert Set is intended for use before conception to induce ovulation. Its safety during pregnancy has not been established, and it is not recommended for use while pregnant. Limited data are available for breastfeeding; therefore, it should only be used under specialist supervision if at all.

To order Meriofert Set, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details, and necessary import documentation.

Meriofert Set combines both FSH and LH in a single injectable formulation, whereas some alternatives provide only recombinant FSH (e.g., Gonal‑F) or separate LH preparations (e.g., Luveris). The combined approach may simplify dosing for certain protocols, but clinical choice depends on individual patient response, physician preference, and cost considerations.

Meriofert Set must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature for a short period during administration, it may be used, but it should be returned to refrigeration promptly.

Meriofert Set is administered by a qualified healthcare professional via intramuscular or subcutaneous injection. The injection site is typically the abdomen or thigh, and the exact technique, volume, and timing are determined by the treating physician according to the individual stimulation protocol.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can cause rapid weight gain, abdominal pain, and respiratory distress; allergic reactions ranging from rash to anaphylaxis; and thromboembolic events such as deep‑vein thrombosis. Patients should be monitored closely for these complications during treatment.

Meriofert Set should not be used in individuals with known hypersensitivity to FSH, LH, or any excipients in the formulation. It is also contraindicated in patients with active ovarian cysts, uncontrolled thyroid disease, certain hormone‑dependent cancers, or severe uncontrolled medical conditions that increase the risk of OHSS or thromboembolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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