Product image of Meriofert Set (Follicle-Stimulating Hormone, Luteinising Hormone) supplied by GNH India

Meriofert Set

Active Ingredient:
Follicle-Stimulating Hormone, Luteinising Hormone
Origin:
EU

Meriofert Set (Follicle-Stimulating Hormone, Luteinising Hormone)

Follicle‑Stimulating Hormone, Luteinising Hormone, the active ingredient in Meriofert Set, is a gonadotropin (biologic) presented as a sterile injectable solution for subcutaneous use. It treats infertility caused by anovulation and supports controlled ovarian stimulation in assisted reproductive technologies.

GNH India supplies Meriofert Set as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert Set acts on the reproductive hormone pathway to restore or enhance ovarian function.

  • Anovulatory infertility: induces follicular development to achieve ovulation.
  • Assisted reproductive technology (IVF) cycles: provides controlled ovarian stimulation for oocyte retrieval.
  • Hypogonadotropic hypogonadism: replaces deficient gonadotropins to restore normal reproductive function.

How It Works

  • Follicle‑Stimulating Hormone and Luteinising Hormone in Meriofert Set bind to their respective FSH and LH receptors on ovarian granulosa and theca cells, activating intracellular signaling that promotes follicular growth, estradiol synthesis, and final maturation leading to ovulation, while also supporting luteinization after ovulation.

Side Effects

Adverse reactions may occur with any gonadotropin therapy.

Common Side Effects

  • Injection site reactions: redness, swelling, or pain at the injection site.
  • Mild ovarian hyperstimulation syndrome: abdominal discomfort and bloating.
  • Headache: mild to moderate intensity.
  • Nausea: occasional episodes.
  • Breast tenderness: mild.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome: rapid weight gain, shortness of breath, and increased risk of thrombosis.
  • Ovarian torsion: acute pelvic pain requiring surgical intervention.
  • Allergic reaction: urticaria, angioedema, or anaphylaxis.

Precautions & Warnings

Careful patient assessment and monitoring are essential when using Meriofert Set.

  • Patient selection: assess for contraindications such as ovarian cysts or uncontrolled thyroid disease.
  • Monitoring: perform ultrasound and estradiol measurements to adjust dose and avoid OHSS.
  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Concurrent medications: avoid estrogen‑containing products that may alter response.
  • Allergy assessment: discontinue if signs of hypersensitivity occur.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meriofert Set may interact with several agents that influence ovarian response or coagulation.

Major Interactions (Avoid)

  • GnRH agonists: may amplify response leading to severe OHSS.
  • Estrogen therapy: can increase risk of ovarian cyst formation.
  • Thyroid hormone excess: may potentiate ovarian response.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for thromboembolic events in OHSS.
  • Diuretics: may mask fluid retention signs.
  • Corticosteroids: may affect estradiol levels.

Frequently Asked Questions

Meriofert Set is used in reproductive medicine to treat infertility caused by anovulation, to provide controlled ovarian stimulation for assisted reproductive technologies such as in‑vitro fertilisation, and to replace deficient gonadotropins in patients with hypogonadotropic hypogonadism.

The FSH component binds to FSH receptors on ovarian granulosa cells, stimulating follicular growth and estradiol production. The LH component binds to LH receptors on theca and luteal cells, promoting androgen conversion, final follicle maturation, and luteinization, together enabling ovulation.

The dose of Meriofert Set is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s clinical condition, response to therapy, and monitoring results.

Meriofert Set is not indicated for use during pregnancy and its safety in breastfeeding has not been established. It should be avoided in pregnant women, and caution is advised for nursing mothers; the prescriber should evaluate risks and benefits.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Meriofert Set combines recombinant FSH and LH, whereas many alternatives provide only FSH (e.g., recombinant FSH alone) or are derived from urinary sources. The combined formulation can more closely mimic natural pituitary secretion, potentially improving follicular response in certain protocols, but choice depends on clinical goals and physician preference.

Meriofert Set must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Once prepared for injection, it should be used within the time frame specified in the product label and kept in the original packaging to maintain stability.

Meriofert Set is given by subcutaneous injection, typically into the abdominal wall or thigh. The product may require reconstitution with a supplied diluent before injection. Administration technique and injection sites should follow the prescribing information and be performed by trained healthcare personnel.

The most serious risks include severe ovarian hyperstimulation syndrome, which can cause rapid weight gain, respiratory distress, and thromboembolic complications, ovarian torsion presenting as acute pelvic pain, and systemic allergic reactions such as anaphylaxis. Prompt medical attention is required if any of these occur.

Meriofert Set should not be used in patients with known hypersensitivity to any component, active ovarian cysts, uncontrolled thyroid disease, pregnancy, or those with severe ovarian failure where stimulation would be ineffective. Contraindications are detailed in the prescribing information and should be reviewed by the prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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