Product image of Meriofert Set (Luteinising Hormone (Human), Follicle-Stimulating Hormone) supplied by GNH India

Meriofert Set

Active Ingredient:
Luteinising Hormone (Human), Follicle-Stimulating Hormone
Origin:
EU

Meriofert Set (Luteinising Hormone (Human), Follicle-Stimulating Hormone)

Human luteinising hormone; Human follicle‑stimulating hormone, the active ingredient in Meriofert Set, is a gonadotropin presented as a sterile injectable solution for intramuscular or subcutaneous use. It is used to treat infertility related to hypogonadotropic hypogonadism, to induce ovulation in women, and to stimulate spermatogenesis in men.

GNH India supplies Meriofert Set as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert Set, a gonadotropin preparation, is employed in reproductive endocrinology to address hormone‑dependent infertility.

  • Infertility due to hypogonadotropic hypogonadism: restores LH and FSH activity to promote gamete production.
  • Induction of ovulation: stimulates follicular development to enable ovulation in women undergoing assisted reproduction.
  • Stimulation of spermatogenesis: enhances testicular testosterone and sperm production in men with deficient gonadotropin secretion.

How It Works

  • Human luteinising hormone and follicle‑stimulating hormone in Meriofert Set bind to LH and FSH receptors on ovarian, testicular and other gonadal cells. This receptor activation triggers intracellular signaling cascades that increase steroid hormone synthesis and support the maturation of oocytes and spermatozoa, thereby facilitating gametogenesis and reproductive function.

Side Effects

Adverse reactions to Meriofert Set may vary in frequency and severity.

Common Side Effects

  • Injection site pain or erythema.
  • Headache.
  • Nausea or mild abdominal discomfort.
  • Transient ovarian hyperstimulation (mild).
  • Mild fluid retention.
  • Transient increase in estradiol levels.

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome.
  • Multiple gestation pregnancy.
  • Allergic reaction or anaphylaxis.
  • Thromboembolic events.
  • Significant ovarian cyst formation.
  • Severe abdominal pain with ascites.

Precautions & Warnings

When using Meriofert Set, clinicians should observe several safety measures.

  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Monitor ovarian response: use ultrasound to avoid excessive stimulation.
  • Assess hormone levels: measure LH, FSH and estradiol during treatment.
  • Risk of multiple gestation: counsel patients on the possibility of twins or higher order pregnancies.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions with Meriofert Set require careful assessment.

Major Interactions (Avoid)

  • GnRH agonists: may blunt the therapeutic response if given concurrently.
  • Oral contraceptives: suppress endogenous gonadotropins, reducing efficacy.
  • High‑dose estrogen therapy: antagonizes gonadotropin action.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone replacement: adjust dosing as thyroid status influences gonadotropin response.
  • Corticosteroids: may affect steroidogenesis pathways.
  • Anticoagulants: monitor for bleeding complications if ovarian hyperstimulation occurs.

Frequently Asked Questions

Meriofert Set is a gonadotropin preparation used to treat infertility caused by hypogonadotropic hypogonadism, to induce ovulation in women undergoing assisted reproductive techniques, and to stimulate spermatogenesis in men with deficient gonadotropin secretion.

The human luteinising hormone and follicle‑stimulating hormone components bind to LH and FSH receptors on ovarian and testicular cells. This activates signaling pathways that increase steroid hormone production and promote the maturation of oocytes and sperm, supporting normal reproductive processes.

The dose of Meriofert Set is individualized and set by the prescribing clinician based on the patient’s hormonal profile, treatment goals and response to therapy. Specific dosing regimens are not provided here.

Meriofert Set is intended for use before conception to achieve pregnancy; it is not indicated for use during pregnancy. Safety data for breastfeeding are limited, and the product should be used with caution, following a physician’s assessment.

To order, submit an enquiry on the Meriofert Set product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Meriofert Set contains both LH and FSH activity in a single formulation, similar to combination products such as Menopur. Compared with separate LH and FSH preparations, it offers convenience of a single injection but may differ in specific dosing ratios, which clinicians consider when selecting therapy.

Meriofert Set should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze the product or shake the vial vigorously. Keep it in the original packaging until use to maintain stability.

The product is supplied as a sterile injectable solution and is administered by a trained healthcare professional via intramuscular or subcutaneous injection, typically into the thigh, buttock or abdominal wall, following aseptic technique.

Serious risks include severe ovarian hyperstimulation syndrome, which can cause abdominal pain, fluid accumulation and electrolyte imbalance, as well as the possibility of multiple gestation pregnancies and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for these events.

Meriofert Set is contraindicated in individuals with known hypersensitivity to human LH or FSH, in patients with active ovarian cysts, uncontrolled thyroid disease, or those who are already pregnant. Caution is also advised for patients with severe cardiovascular disease or a history of thromboembolic events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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