Product image of Meriofert Spuit (Luteinising Hormone (Human), Follicle-Stimulating Hormone) supplied by GNH India

Meriofert Spuit

Active Ingredient:
Luteinising Hormone (Human), Follicle-Stimulating Hormone
Origin:
EU

Meriofert Spuit (Luteinising Hormone (Human), Follicle-Stimulating Hormone)

Human Menopausal Gonadotropin, the active ingredient in Meriofert Spuit, is a gonadotropin presented as an injectable solution for intramuscular or subcutaneous use. It stimulates ovarian follicular development and ovulation in women with anovulation or hypogonadotropic hypogonadism.
GNH India supplies Meriofert Spuit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Meriofert Spuit is a gonadotropin used in reproductive‑hormone pathways to promote follicular growth and ovulation.

  • Induction of ovulation in women with anovulation: restores natural ovulatory cycles to enable conception.
  • Controlled ovarian stimulation for assisted reproductive technologies: enhances follicle recruitment for IVF or ICSI procedures.
  • Treatment of hypogonadotropic hypogonadism: replaces deficient LH and FSH to support normal ovarian function.

How It Works

  • Human Menopausal Gonadotropin contains both LH and FSH molecules that bind to their respective receptors on ovarian granulosa and theca cells. Activation of these receptors triggers intracellular signaling cascades that promote follicular maturation, estrogen synthesis, and the final ovulatory surge, thereby facilitating oocyte release and supporting early luteal phase function.

Side Effects

Adverse reactions may occur with any injectable reproductive hormone therapy.

Common Side Effects

  • Injection site pain or erythema: mild discomfort at the administration site.
  • Abdominal bloating or discomfort: transient gastrointestinal symptoms.
  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Mild ovarian cyst formation: small, self‑limiting cysts.

Serious or Rare Side Effects

  • Ovarian hyperstimulation syndrome (OHSS): severe fluid shift and abdominal distension.
  • Multiple pregnancy: higher-order gestations requiring specialized care.
  • Thromboembolic events: rare clot formation in veins.
  • Severe allergic reaction: anaphylaxis with rash, swelling, or breathing difficulty.
  • Ovarian torsion: acute pelvic pain due to twisted ovary.

Precautions & Warnings

Use Meriofert Spuit only under specialist supervision with appropriate monitoring.

  • Baseline assessment: evaluate ovarian reserve and hormonal profile before initiating therapy.
  • Monitor estradiol: frequent serum estradiol measurements to detect excessive response.
  • Avoid in pregnancy: contraindicated in confirmed pregnancy; ensure effective contraception.
  • Caution with ovarian cysts: assess for existing cysts prior to treatment.
  • Screen for hormone‑sensitive tumors: avoid use in patients with active estrogen‑dependent cancers.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Drug interactions may modify the efficacy or safety of Meriofert Spuit.

Major Interactions (Avoid)

  • Concurrent use of other gonadotropins: may cause excessive ovarian stimulation.
  • High‑dose estrogen therapy: can blunt the intended ovarian response.

Moderate Interactions (Monitor Closely)

  • GnRH agonists or antagonists: may require dose adjustment of hMG.
  • Anticoagulants: monitor for increased bleeding risk at injection sites.
  • Corticosteroids: may alter hormonal metabolism and require observation.

Frequently Asked Questions

Meriofert Spuit is an injectable preparation of human menopausal gonadotropin (LH and FSH) used to induce ovulation in women with anovulation, to stimulate the ovaries during assisted reproductive technologies such as IVF, and to treat hypogonadotropic hypogonadism by replacing deficient gonadotropins.

The preparation contains both luteinising hormone (LH) and follicle‑stimulating hormone (FSH). These hormones bind to LH and FSH receptors on ovarian cells, activating signaling pathways that promote follicle growth, estrogen production, and the final ovulatory surge, thereby enabling oocyte release and supporting early luteal function.

The dose of Meriofert Spuit is individualized. A qualified prescriber determines the amount, frequency, and duration based on the patient’s ovarian reserve, response to treatment, and the specific assisted‑reproduction protocol being used.

Meriofert Spuit is contraindicated in confirmed pregnancy and should not be used by women who are breastfeeding. It is intended for use before conception to induce ovulation; safety data in pregnancy and lactation are not established.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Compared with recombinant FSH or LH products, Meriofert Spuit provides a combined LH/FSH formulation derived from human urine, offering a broader hormonal profile. It may be preferred in protocols requiring both hormones, while recombinant preparations deliver highly purified single‑component dosing. Choice depends on clinical protocol, cost considerations, and patient response.

Meriofert Spuit must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the vials in their original packaging until use and discard any product that appears discolored or contains particles.

The product is supplied as a sterile injectable solution for intramuscular or subcutaneous injection. Administration is performed by a qualified healthcare professional using aseptic technique, typically in the gluteal muscle or abdominal subcutaneous tissue, according to the prescriber’s dosing schedule.

The most serious risks include ovarian hyperstimulation syndrome (OHSS), which can cause severe abdominal pain, fluid accumulation, and thromboembolic complications, as well as the possibility of multiple pregnancy and rare severe allergic reactions such as anaphylaxis. Patients should be monitored closely for these events.

Meriofert Spuit should not be used in women who are already pregnant, have uncontrolled thyroid disease, active estrogen‑dependent tumors, untreated ovarian cysts, severe ovarian failure, or known hypersensitivity to any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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