Product image of Meropenem Steriscience (Meropenem) supplied by GNH India

Meropenem Steriscience

Active Ingredient:
Meropenem
Origin:
EU

Meropenem Steriscience (Meropenem)

Meropenem, the active ingredient in Meropenem Steriscience, is a carbapenem presented as an injectable solution for intravenous use. It treats severe bacterial infections such as complicated intra‑abdominal infections, hospital‑acquired pneumonia, and meningitis in hospitalized patients.

GNH India supplies Meropenem Steriscience as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Steriscience B.V.

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Indications & Clinical Uses

  • Meropenem is a broad‑spectrum carbapenem antibiotic used to treat serious Gram‑negative and Gram‑positive infections.
  • Complicated intra‑abdominal infections: provides bacterial eradication and clinical cure in patients with intra‑abdominal sepsis.
  • Complicated urinary tract infections: eliminates pathogenic organisms and resolves infection symptoms.
  • Hospital‑acquired pneumonia: achieves microbiological clearance and improves respiratory function.
  • Ventilator‑associated pneumonia: restores lung health and reduces mortality risk.
  • Meningitis: penetrates the cerebrospinal fluid to eradicate causative bacteria.
  • Severe sepsis and septic shock: rapidly reduces bacterial load to support hemodynamic recovery.

How It Works

  • Meropenem binds with high affinity to penicillin‑binding proteins (PBPs) on bacterial cell walls, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial cell lysis. Its broad spectrum includes many Gram‑negative, Gram‑positive and anaerobic organisms, and it resists most β‑lactamases.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Rash or pruritus
  • Elevated liver enzymes (ALT, AST)
  • Injection‑site pain or phlebitis

Serious or Rare Side Effects

  • Seizures, especially in patients with CNS disorders
  • Clostridioides difficile‑associated colitis
  • Anaphylactic or severe hypersensitivity reactions
  • Acute renal failure or nephrotoxicity
  • Severe neutropenia or thrombocytopenia
  • Hepatic failure or jaundice

Precautions & Warnings

Careful assessment and monitoring are essential when using Meropenem.

  • Renal function: evaluate creatinine clearance and adjust dose as needed.
  • Seizure risk: avoid in patients with a history of epilepsy or CNS disease.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Hypersensitivity: discontinue if signs of an allergic reaction appear.
  • Concomitant nephrotoxic drugs: use with caution to prevent renal injury.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meropenem may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Valproic acid: carbapenems can lower valproate levels, risking seizure breakthrough.
  • Probenecid: may reduce renal clearance of Meropenem, increasing toxicity.
  • Aminoglycosides: combined use can enhance nephrotoxic potential.

Moderate Interactions (Monitor Closely)

  • Warfarin: monitor INR as Meropenem may alter anticoagulant effect.
  • Oral contraceptives: efficacy may be reduced; advise alternative contraception.

Frequently Asked Questions

Meropenem Steriscience is indicated for serious bacterial infections such as complicated intra‑abdominal infections, complicated urinary tract infections, hospital‑acquired and ventilator‑associated pneumonia, meningitis, severe sepsis, septic shock, and febrile neutropenia. It is administered intravenously in hospitalized patients who need broad‑spectrum coverage.

Meropenem inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins. This blocks the cross‑linking of peptidoglycan strands, weakening the wall and causing osmotic lysis of the bacterium. Its structure resists most β‑lactamases, giving it activity against many resistant Gram‑negative and Gram‑positive organisms.

The specific dose and infusion rate of Meropenem Steriscience are determined by the prescribing clinician based on infection severity, pathogen susceptibility, patient weight, renal function, and other clinical factors. Healthcare professionals tailor the regimen to achieve optimal therapeutic outcomes.

Safety data for Meropenem in pregnancy and lactation are limited, and the product carries an unknown pregnancy category. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and clinicians should assess each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Meropenem shares the carbapenem class’s broad‑spectrum activity and β‑lactamase stability, but it offers a slightly lower risk of neurotoxicity compared with imipenem and a convenient dosing schedule. Compared with ertapenem, Meropenem provides better coverage against Pseudomonas aeruginosa, making it suitable for more severe hospital‑acquired infections.

Meropenem Steriscience must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking. Once reconstituted, use the solution within the time frame specified in the product labeling and maintain cold‑chain conditions during transport.

The medication is supplied as an injectable solution for intravenous infusion. It is typically administered over a 15‑30‑minute infusion period, but the exact rate and duration are determined by the treating physician based on the infection type, patient condition, and renal function.

Serious adverse events include seizures, especially in patients with pre‑existing CNS disorders, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and significant renal or hepatic impairment. Prompt recognition and discontinuation are essential if any of these events occur.

Patients with a known hypersensitivity to Meropenem, other carbapenems, or any β‑lactam antibiotics should avoid this product. Caution is also advised for individuals with a history of seizures, severe renal or hepatic dysfunction, or those receiving interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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