Product image of Meropenem Steriscience (Meropenem) supplied by GNH India

Meropenem Steriscience

Active Ingredient:
Meropenem
Origin:
EU

Meropenem Steriscience (Meropenem)

Meropenem, the active ingredient in Meropenem Steriscience, is a carbapenem presented as an injection for intravenous use. It is indicated for the treatment of severe bacterial infections, including complicated intra‑abdominal infections, complicated urinary tract infections, hospital‑acquired and ventilator‑associated pneumonia, meningitis, and sepsis in hospitalized adults.

GNH India supplies Meropenem Steriscience as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with support for regulatory compliance, cold‑chain logistics where required, and reliable global distribution.

Manufacturer / TM Owner

Steriscience B.V.

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Indications & Clinical Uses

  • Meropenem is a carbapenem antibiotic used to treat serious bacterial infections affecting various organ systems.
  • Complicated intra‑abdominal infections: provides broad‑spectrum coverage to eradicate Gram‑negative, Gram‑positive and anaerobic pathogens.
  • Complicated urinary tract infections: achieves rapid bacterial clearance in resistant uropathogens.
  • Hospital‑acquired pneumonia: delivers effective therapy against multidrug‑resistant organisms.
  • Ventilator‑associated pneumonia: penetrates lung tissue to treat severe ventilator‑related infections.
  • Meningitis: attains therapeutic concentrations in cerebrospinal fluid for bacterial meningitis.
  • Sepsis: offers rapid bactericidal activity in systemic infections.

How It Works

  • Meropenem exerts its antibacterial effect by binding to penicillin‑binding proteins (PBPs) on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption leads to cell‑wall weakening and osmotic lysis. The molecule is resistant to most β‑lactamases, providing broad‑spectrum activity against Gram‑negative, Gram‑positive and anaerobic bacteria.

Side Effects

Adverse reactions reported with meropenem may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: may be watery and self‑limiting.
  • Vomiting: occasional post‑infusion emesis.
  • Headache: transient cranial discomfort.
  • Infusion site reactions: erythema or phlebitis at the injection site.
  • Elevated liver enzymes: transient increase in transaminases.

Serious or Rare Side Effects

  • Seizures: especially in patients with renal impairment or CNS disorders.
  • Clostridioides difficile infection: severe colitis risk.
  • Anaphylaxis: acute hypersensitivity reaction.
  • Stevens‑Johnson syndrome: rare severe skin eruption.
  • Renal toxicity: acute kidney injury in susceptible individuals.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

  • Meropenem should be used with caution in specific clinical situations.
  • Renal impairment: adjust dose according to creatinine clearance.
  • Hypersensitivity: avoid in patients with known carbapenem or β‑lactam allergy.
  • Pregnancy: category B; weigh benefits against potential risks.
  • CNS disorders: monitor for seizures in patients with epilepsy or brain injury.
  • C. difficile risk: monitor for signs of colitis during and after therapy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meropenem may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Valproic acid: carbapenems can reduce serum valproate levels, risking seizure breakthrough.
  • High‑dose aminoglycosides: combined nephrotoxicity may be additive.
  • Loop diuretics: may increase risk of renal dysfunction.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation.
  • Oral contraceptives: possible reduced effectiveness, advise backup method.
  • Other β‑lactam antibiotics: antagonistic effect, avoid concurrent use.
  • Diuretics: monitor electrolytes and renal function.

Frequently Asked Questions

Meropenem Steriscience is a carbapenem antibiotic indicated for the treatment of severe bacterial infections such as complicated intra‑abdominal infections, complicated urinary tract infections, hospital‑acquired and ventilator‑associated pneumonia, bacterial meningitis and systemic sepsis in hospitalized patients.

Meropenem binds to penicillin‑binding proteins on the bacterial cell wall, blocking the final step of peptidoglycan cross‑linking. This inhibition weakens the cell wall, causing osmotic rupture and bacterial death. Its structure also confers resistance to most β‑lactamases, giving it broad‑spectrum activity.

The exact dose and infusion rate are determined by the prescribing clinician based on the type and severity of infection, the patient’s renal function, weight and other clinical factors. Dosing regimens are individualized and should follow local guidelines and the prescriber’s judgment.

Meropenem is classified as pregnancy category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used when the benefit outweighs potential risk. Small amounts are excreted in breast milk; caution is advised and the infant should be monitored.

To place an order, submit an enquiry on the Meropenem Steriscience product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Meropenem shares the broad‑spectrum, β‑lactamase‑resistant profile of the carbapenem class but has a slightly lower affinity for some Pseudomonas strains compared with imipenem‑cilastatin. Compared with non‑carbapenem agents, it offers superior activity against multidrug‑resistant Gram‑negative organisms and anaerobes, making it a preferred option for severe hospital‑acquired infections.

Meropenem Steriscience is supplied as a sterile powder for injection. After reconstitution, the solution should be stored at 2‑8 °C, protected from light, and used within the time frame specified in the product label. Unreconstitated vials must remain refrigerated and must not be frozen or shaken.

The product is administered intravenously. The powder is reconstituted with the appropriate diluent, then further diluted in compatible IV fluids. It is infused over a period usually ranging from 15 minutes to 30 minutes, depending on the dose and clinical protocol, under aseptic conditions.

Serious adverse events include seizures, especially in patients with renal impairment or pre‑existing CNS disorders, severe hypersensitivity reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Clinicians should monitor neurological status, renal function and signs of severe skin or gastrointestinal reactions throughout therapy.

Patients with a documented hypersensitivity to meropenem, other carbapenems or any β‑lactam antibiotics should avoid this product. It is also contraindicated in neonates with a gestational age less than 32 weeks for certain indications, and caution is required in individuals with severe renal dysfunction or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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