Product image of Meropenem Steriscience (Meropenem) supplied by GNH India

Meropenem Steriscience

Active Ingredient:
Meropenem
Origin:
EU

Meropenem Steriscience (Meropenem)

Meropenem, the active ingredient in Meropenem Steriscience, is a carbapenem antibiotic presented as an injection for intravenous use. It treats severe bacterial infections such as complicated intra‑abdominal infections, complicated urinary tract infections, nosocomial pneumonia, meningitis, and severe sepsis in hospitalized patients.

GNH India supplies Meropenem Steriscience as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Steriscience B.V.

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Indications & Clinical Uses

  • Meropenem is a broad‑spectrum carbapenem used for serious bacterial infections that are resistant to other agents.
  • Complicated intra‑abdominal infections: provides bacterial eradication and clinical cure in patients with intra‑abdominal sepsis.
  • Complicated urinary tract infections: eliminates resistant uropathogens and resolves infection.
  • Nosocomial pneumonia: treats hospital‑acquired lung infections caused by multidrug‑resistant organisms.
  • Meningitis: penetrates the cerebrospinal fluid to eradicate causative bacteria.
  • Severe sepsis and septic shock: offers rapid bactericidal activity in critically ill patients.

How It Works

  • Meropenem binds to penicillin‑binding proteins on bacterial cell walls, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis. Its high affinity for a broad range of PBPs gives it activity against many Gram‑negative, Gram‑positive, and anaerobic organisms, including those resistant to other β‑lactams.

Side Effects

Adverse reactions may occur with meropenem therapy.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: may be watery and self‑limiting.
  • Rash: non‑specific skin eruption.
  • Injection site phlebitis: localized pain or redness.
  • Elevated liver enzymes: transient hepatic enzyme rise.
  • Headache: mild discomfort.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: risk increased in patients with CNS disorders or renal impairment.
  • Clostridioides difficile colitis: severe diarrhea due to overgrowth.
  • Renal toxicity: acute kidney injury in susceptible individuals.
  • Severe neutropenia: marked reduction in white blood cells.
  • Stevens‑Johnson syndrome: rare mucocutaneous blistering disorder.

Precautions & Warnings

  • Use meropenem with careful clinical monitoring.
  • Renal function: adjust dose in patients with impaired renal clearance.
  • Seizure risk: monitor patients with a history of seizures or CNS disease.
  • Allergy: avoid in individuals with known carbapenem hypersensitivity.
  • Pregnancy: prescribe only when benefit outweighs potential risk to the fetus.
  • Superinfection: watch for secondary fungal or bacterial infections.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Meropenem may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Valproic acid: may reduce serum concentrations, decreasing seizure control.
  • Aminoglycosides: combined use can increase nephrotoxicity.
  • Loop diuretics: heightened risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Probenecid: can increase meropenem plasma levels, necessitating dose review.
  • Phenytoin: may alter seizure threshold, requiring clinical observation.

Frequently Asked Questions

Meropenem Steriscience is indicated for serious bacterial infections such as complicated intra‑abdominal infections, complicated urinary tract infections, hospital‑acquired (nosocomial) pneumonia, bacterial meningitis, and severe sepsis or septic shock. It is reserved for cases where pathogens are resistant to other antibiotics.

Meropenem inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins. This blocks the cross‑linking of peptidoglycan strands, weakening the wall and causing osmotic lysis of the bacterium. Its broad affinity for many PBPs gives activity against a wide range of Gram‑positive, Gram‑negative, and anaerobic organisms.

The dosage of Meropenem Steriscience is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and local antimicrobial guidelines. Only a qualified healthcare professional should set the appropriate dose and infusion rate.

The safety of meropenem in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and any required import documentation.

Meropenem shares the carbapenem class’s broad‑spectrum activity and resistance to many β‑lactamases, but it has a slightly lower affinity for some Pseudomonas aeruginosa strains compared with imipenem. It is often preferred when a lower risk of seizures is desired, as it has a more favorable neurotoxicity profile.

Meropenem Steriscience should be stored at 2‑8 °C in a refrigerator. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

The product is supplied as a sterile powder for injection and must be reconstituted with the appropriate diluent. It is administered intravenously, typically as a short infusion over 15‑30 minutes, under the supervision of a qualified healthcare professional.

Serious adverse events include anaphylactic reactions, seizures (especially in patients with renal impairment or pre‑existing CNS disorders), Clostridioides difficile‑associated colitis, severe renal toxicity, and rare severe skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if any of these occur.

Meropenem Steriscience is contraindicated in patients with a known hypersensitivity to meropenem, other carbapenems, or any component of the formulation. Caution is also advised for patients with a history of seizures, severe renal impairment, or previous severe allergic reactions to β‑lactam antibiotics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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