Product image of Meropur (Menotrophin) supplied by GNH India

Meropur

Active Ingredient:
Menotrophin
Origin:
EU

Meropur (Menotrophin)

Menotrophin, the active ingredient in Meropur, is a gonadotropin (FSH and LH preparation) presented as a sterile solution for intramuscular, subcutaneous use. It treats infertility in women by stimulating ovarian follicular development and ovulation.
GNH India supplies Meropur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ferring S.P.A.

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Indications & Clinical Uses

Meropur is a gonadotropin preparation used in reproductive medicine to support follicular growth and ovulation.

  • Ovulation induction: promotes the development of a dominant follicle to trigger ovulation in anovulatory women.
  • Controlled ovarian hyperstimulation: enhances multiple follicle development for assisted reproductive technologies such as IVF.
  • Infertility treatment: improves the chances of conception in couples experiencing female factor infertility.

How It Works

  • Menotrophin contains both follicle‑stimulating hormone (FSH) and luteinising hormone (LH) activity. After intramuscular or subcutaneous administration, it binds to ovarian FSH and LH receptors, stimulating granulosa cell proliferation, estrogen synthesis, and the final maturation of ovarian follicles, thereby facilitating ovulation and supporting controlled ovarian hyperstimulation protocols.

Side Effects

Adverse reactions may occur with Menotrophin therapy and are categorized by frequency.

Common Side Effects

  • Injection site pain or erythema
  • Abdominal discomfort or bloating
  • Headache
  • Nausea or mild vomiting
  • Breast tenderness
  • Mild ovarian hyperstimulation

Serious or Rare Side Effects

  • Severe ovarian hyperstimulation syndrome (OHSS)
  • Multiple pregnancy
  • Allergic reactions including rash or anaphylaxis
  • Thromboembolic events
  • Pulmonary edema
  • Severe abdominal pain with ascites

Precautions & Warnings

Before initiating Menotrophin therapy, clinicians should consider several safety measures.

  • Baseline assessment: evaluate ovarian reserve and baseline estradiol levels.
  • Monitoring: perform regular ultrasound and hormone monitoring to detect excessive response.
  • Hypersensitivity: avoid in patients with known allergy to gonadotropins or excipients.
  • Cysts or tumors: contraindicated in the presence of ovarian cysts or estrogen‑dependent neoplasms.
  • Thyroid disease: use caution in uncontrolled thyroid disorders.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Menotrophin may interact with other agents that influence ovarian function or coagulation.

Major Interactions (Avoid)

  • GnRH agonists: can cause excessive ovarian stimulation when combined.
  • hCG: increases risk of severe ovarian hyperstimulation syndrome.
  • Estrogen‑containing contraceptives: may blunt the intended gonadotropin effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: heightened thrombosis risk if severe OHSS develops.
  • Corticosteroids: may alter follicular response and hormone levels.

Frequently Asked Questions

Meropur contains Menotrophin, a combination of FSH and LH activity, and is used to induce ovulation, support controlled ovarian hyperstimulation for assisted reproductive technologies, and treat female infertility by promoting follicular development.

Menotrophin provides exogenous FSH and LH, binding to their respective ovarian receptors. This stimulates granulosa cell proliferation, estrogen production, and the maturation of ovarian follicles, ultimately leading to ovulation and the preparation of the uterus for potential implantation.

The dose of Meropur is individualized. The prescribing clinician determines the amount, frequency, and duration based on the patient's ovarian response, treatment protocol, and monitoring results.

Meropur is intended for use before conception to facilitate ovulation. Its safety in established pregnancy or while breastfeeding has not been established, and it should not be used during those periods without specialist guidance.

To order Meropur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Meropur provides both FSH and LH activity in a single preparation, whereas some alternatives offer only FSH (e.g., recombinant FSH) or require separate LH supplementation. This combined approach can simplify dosing and may be advantageous in protocols that need both hormones for optimal follicular development.

Meropur should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. If temporary storage at room temperature is unavoidable, limit exposure to less than 24 hours and keep the product in its original packaging.

Meropur is supplied as a sterile solution for injection. It can be given either intramuscularly or subcutaneously, according to the prescriber's instructions. Proper aseptic technique and correct needle size should be used for each administration.

The most serious risks include severe ovarian hyperstimulation syndrome (OHSS), which can lead to fluid accumulation, thromboembolic events, and multiple pregnancy. Prompt monitoring of ovarian response and estradiol levels helps mitigate these risks.

Meropur is contraindicated in patients with known hypersensitivity to Menotrophin or any excipients, those with ovarian cysts or estrogen‑dependent tumors, uncontrolled thyroid disease, and in women who are already pregnant or breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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