Product image of Mesagran (Mesalazine) supplied by GNH India

Mesagran

Active Ingredient:
Mesalazine
Origin:
EU

Mesagran (Mesalazine)

Mesalazine, the active ingredient in Mesagran, is a 5‑aminosalicylic acid (5‑ASA) presented as an oral formulation for prescription use. It is employed to manage inflammatory bowel disease, specifically ulcerative colitis and Crohn's disease, by reducing intestinal inflammation in affected patients.

GNH India supplies Mesagran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Falk Pharma G.M.B.H.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Mesalazine is used within the inflammatory bowel disease therapeutic area to control mucosal inflammation.

  • Ulcerative colitis: helps induce and maintain remission by decreasing colonic inflammation.
  • Crohn's disease: reduces intestinal inflammation and supports symptom control in affected segments.
  • Maintenance therapy: sustains remission after induction therapy, limiting flare‑ups.

How It Works

  • Mesalazine releases mesalazine locally in the intestinal lumen where it inhibits cyclooxygenase and lipoxygenase pathways, leading to reduced synthesis of prostaglandins and leukotrienes. This local anti‑inflammatory action diminishes mucosal immune activation and promotes healing of the intestinal lining in inflammatory bowel disease.

Side Effects

Mesalazine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Abdominal pain: cramping or discomfort in the gut.
  • Headache: transient head pain.
  • Rash: skin irritation or mild dermatitis.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, breathing difficulty, or hives.
  • Blood in stool: indicates possible colitis flare or ulceration.
  • Liver enzyme elevation: signs of hepatic stress.
  • Pancreatitis: abdominal pain with elevated enzymes.
  • Kidney dysfunction: reduced renal function or interstitial nephritis.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific risk factors and monitor for potential complications.

  • Renal function monitoring: assess baseline and periodic kidney tests.
  • Hepatic function monitoring: check liver enzymes before and during treatment.
  • Disease activity assessment: ensure active disease is present before starting.
  • Hypersensitivity avoidance: discontinue if allergic reaction occurs.
  • Pregnancy considerations: use only if benefits outweigh potential risks.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mesalazine can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Azathioprine: increased risk of bone marrow suppression.
  • Warfarin: may enhance anticoagulant effect, raising bleeding risk.
  • Methotrexate: potential additive toxicity on liver and bone marrow.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase gastrointestinal irritation.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Lithium: monitor lithium levels for potential increase.

Frequently Asked Questions

Mesagran contains mesalazine, which is prescribed for inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It helps reduce intestinal inflammation, supporting remission induction and maintenance in adult patients.

Mesalazine acts locally in the gut by inhibiting cyclooxygenase and lipoxygenase enzymes, which lowers prostaglandin and leukotriene production. This reduces inflammatory signaling in the intestinal mucosa, helping to control the symptoms of IBD.

The dosage of Mesagran is individualized by the prescribing clinician based on disease severity, patient weight, and response to therapy. Healthcare professionals determine the appropriate strength and frequency for each patient.

Safety data for mesalazine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Mesagran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesagran (mesalazine) belongs to the 5‑ASA class, offering a topical anti‑inflammatory effect within the gut. Compared with systemic steroids or biologics, it generally has a more favorable safety profile but may be less potent for severe disease, making it suitable for mild to moderate cases or maintenance therapy.

Mesagran should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, heat and direct sunlight to maintain product stability.

Mesagran is taken orally, usually with water. The tablet should be swallowed whole unless the prescribing information advises otherwise. Dosing times and frequency are set by the prescriber to match the individual treatment plan.

Serious risks include severe allergic reactions, blood in the stool indicating possible ulceration, liver enzyme elevation, pancreatitis, and kidney dysfunction. Patients should be monitored regularly, and any alarming symptoms should prompt immediate medical evaluation.

Mesagran is contraindicated in patients with known hypersensitivity to mesalazine or any component of the formulation. Caution is also advised for individuals with severe renal or hepatic impairment, and it should be avoided in those with active severe ulcerative colitis requiring more aggressive therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Mesalazine

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT