Product image of Mesalazin Orion (Mesalazine) supplied by GNH India

Mesalazin Orion

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazin Orion (Mesalazine)

Mesalazine, the active ingredient in Mesalazin Orion, is a aminosalicylate presented as an oral dosage form for oral use. It treats ulcerative colitis and Crohn's disease by reducing intestinal inflammation in adult patients.

GNH India supplies Mesalazin Orion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Faes Farma S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Mesalazin Orion is used in the management of inflammatory bowel disease, targeting mucosal inflammation.

  • Ulcerative colitis: induces remission and maintains disease control by decreasing colonic inflammation.
  • Crohn's disease: reduces intestinal lesions and symptoms, supporting long‑term disease management.
  • Maintenance therapy: helps prevent relapse after induction of remission in IBD patients.

How It Works

  • Mesalazine acts locally in the intestinal mucosa by inhibiting cyclooxygenase and lipoxygenase pathways, which lowers the synthesis of prostaglandins and leukotrienes. This anti‑inflammatory action reduces mucosal irritation and promotes healing in the gastrointestinal tract.

Side Effects

Mesalazin Orion may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Abdominal pain: cramping or discomfort in the gut.
  • Headache: transient mild headaches.
  • Flatulence: increased intestinal gas.
  • Rash: skin irritation or mild erythema.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, swelling, or difficulty breathing.
  • Blood disorders: neutropenia or agranulocytosis.
  • Hepatic enzyme elevation: signs of liver injury.
  • Pancreatitis: abdominal pain with elevated enzymes.
  • Nephritis: kidney inflammation or dysfunction.
  • Severe colitis flare: worsening of underlying disease.

Precautions & Warnings

Before prescribing Mesalazin Orion, clinicians should consider several safety measures.

  • Renal function monitoring: assess kidney status regularly.
  • Hepatic function monitoring: check liver enzymes during therapy.
  • Disease severity assessment: ensure appropriate indication before initiation.
  • Hypersensitivity avoidance: do not use in patients with known mesalazine allergy.
  • Pregnancy caution: evaluate risk‑benefit as safety data are limited.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mesalazin Orion can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Azathioprine: increased risk of bone marrow suppression.
  • Warfarin: potentiation of anticoagulant effect, raising INR.
  • Sulfasalazine: additive toxicity, especially to kidneys.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened gastrointestinal irritation.
  • Oral contraceptives: possible reduction in contraceptive efficacy.
  • Methotrexate: increased hepatic toxicity risk.

Frequently Asked Questions

Mesalazin Orion contains mesalazine, which is prescribed for the treatment of ulcerative colitis and Crohn's disease. It works by reducing inflammation in the intestinal lining, helping to induce remission and maintain disease control in adult patients with inflammatory bowel disease.

Mesalazine exerts its effect locally in the gut by inhibiting cyclooxygenase and lipoxygenase enzymes. This reduces the production of prostaglandins and leukotrienes, key mediators of inflammation, thereby decreasing mucosal irritation and promoting healing of the intestinal lining.

The specific dose of Mesalazin Orion is determined by the prescribing physician based on the individual patient's disease severity, location, and response to therapy. Dosage regimens are tailored to each patient and should follow the prescriber's instructions.

Safety data for mesalazine in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies if appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To request Mesalazin Orion, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mesalazin Orion belongs to the aminosalicylate class, offering a topical anti‑inflammatory effect within the gut. Compared with systemic immunosuppressants or biologics, it generally has a more favorable safety profile but may be less potent for severe disease. Choice of therapy depends on disease severity, patient tolerance, and treatment goals.

Mesalazin Orion should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain its stability and potency throughout its shelf life.

Mesalazin Orion is taken orally, usually with water. The exact administration schedule—such as once or multiple times daily—depends on the prescriber's instructions and the specific formulation provided.

Serious risks include severe allergic reactions (anaphylaxis), blood disorders like neutropenia, liver enzyme elevations indicating hepatic injury, pancreatitis, and kidney inflammation. Patients should be monitored regularly for these rare but potentially life‑threatening events.

Mesalazin Orion is contraindicated in individuals with a known hypersensitivity to mesalazine or other aminosalicylates. It should also be used with caution in patients with severe renal or hepatic impairment, and it is not recommended for children unless specifically prescribed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.