Product image of Mesalazin Orion (Mesalazine) supplied by GNH India

Mesalazin Orion

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazin Orion (Mesalazine)

Mesalazine, the active ingredient in Mesalazin Orion, is a 5‑aminosalicylic acid (5‑ASA) presented as a rectal formulation for local use in the colon. It is employed to reduce inflammation associated with ulcerative colitis and other inflammatory bowel conditions in adult patients.

GNH India supplies Mesalazin Orion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Faes Farma, S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Mesalazin Orion is a 5‑ASA drug used to manage inflammatory bowel disease by targeting colonic inflammation.

  • Ulcerative colitis: induces remission and reduces disease activity in mild to moderate cases.
  • Maintenance of remission in ulcerative colitis: helps sustain symptom‑free periods after induction therapy.
  • Pouchitis: alleviates inflammation in the ileal pouch following colectomy.

How It Works

  • Mesalazine exerts its anti‑inflammatory effect by inhibiting cyclooxygenase and lipoxygenase pathways, which reduces prostaglandin and leukotriene synthesis in the colonic mucosa. It also modulates immune cell activity, decreasing cytokine release and stabilising the epithelial barrier, thereby limiting local inflammatory responses.

Side Effects

Mesalazin Orion may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Abdominal pain: discomfort or cramping in the lower abdomen.
  • Nausea: feeling of sickness or urge to vomit.
  • Headache: mild to moderate pain in the head.
  • Flatulence: increased intestinal gas.
  • Rectal irritation: burning or itching at the site of administration.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or difficulty breathing.
  • Severe colitis: worsening inflammation requiring medical attention.
  • Blood in stool: visible bleeding indicating mucosal injury.
  • Liver enzyme elevation: abnormal liver function tests.
  • Pancreatitis: inflammation of the pancreas presenting with abdominal pain and nausea.

Precautions & Warnings

Before initiating therapy with Mesalazin Orion, consider the following safety measures.

  • Renal function assessment: evaluate kidney health, especially in patients with pre‑existing impairment.
  • Hypersensitivity monitoring: watch for signs of allergic reactions during treatment.
  • Disease severity evaluation: ensure appropriate use based on ulcerative colitis activity.
  • Salicylate allergy avoidance: do not prescribe to patients with known hypersensitivity to aspirin or other salicylates.
  • Pregnancy considerations: use only if potential benefits outweigh unknown risks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mesalazin Orion can interact with several medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Methotrexate: heightened toxicity and bone marrow suppression.
  • Azathioprine: amplified risk of myelosuppression.
  • Live vaccines: potential for reduced vaccine efficacy or infection.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • Diuretics: possible impact on renal clearance.
  • Lithium: may increase serum lithium concentrations.

Frequently Asked Questions

Mesalazin Orion is prescribed for ulcerative colitis and related inflammatory bowel disease manifestations. It helps induce remission, maintain symptom‑free periods, and can be used to treat inflammation of an ileal pouch (pouchitis) following surgery.

Mesalazine blocks the cyclooxygenase and lipoxygenase enzymes in the colon, lowering prostaglandin and leukotriene production. It also modulates immune cell activity, decreasing cytokine release and strengthening the intestinal barrier, which together reduce local inflammation.

The specific dose and frequency of Mesalazin Orion are determined by the prescribing clinician based on disease severity, patient weight, and response to therapy. Healthcare providers tailor the regimen to each individual’s needs.

The safety of Mesalazin Orion in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To request Mesalazin Orion, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Mesalazin Orion belongs to the 5‑ASA class, offering a topical anti‑inflammatory effect directly in the colon. Compared with systemic steroids or immunomodulators, it generally has a more favorable safety profile but may be less potent for severe disease, making it suitable for mild‑to‑moderate ulcerative colitis or maintenance therapy.

Mesalazin Orion should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain stability and efficacy.

Mesalazin Orion is a rectal formulation, typically supplied as suppositories or enemas. It is inserted into the rectum according to the prescriber’s instructions, allowing the medication to act locally on the colonic mucosa.

Serious risks include severe allergic reactions, worsening colitis, gastrointestinal bleeding, liver enzyme abnormalities, and pancreatitis. Patients should seek immediate medical attention if they experience rash, swelling, blood in stool, persistent abdominal pain, or jaundice.

Mesalazin Orion is contraindicated in individuals with known hypersensitivity to mesalazine, other 5‑ASA compounds, or salicylates. It should also be avoided in patients with severe renal impairment or active severe ulcerative colitis requiring systemic therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Mesalazine

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT