Product image of Mesalazina Eg (Mesalazine) supplied by GNH India

Mesalazina Eg

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazina Eg (Mesalazine)

Mesalazine, the active ingredient in Mesalazina Eg, is an aminosalicylate presented as a rectal formulation for local use in the colon. It is employed to reduce inflammation associated with ulcerative colitis and proctitis, providing targeted symptom relief for patients with inflammatory bowel disease.

GNH India supplies Mesalazina Eg, an EU‑origin product, as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Eg S.P.A.

1
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Indications & Clinical Uses

  • Mesalazine acts locally in the colon to treat inflammatory bowel disease conditions.
  • Ulcerative colitis: reduces mucosal inflammation and helps maintain remission.
  • Proctitis: alleviates rectal inflammation and improves bowel symptoms.
  • Maintenance therapy: supports long‑term disease control in ulcerative colitis patients.

How It Works

  • Mesalazine inhibits cyclooxygenase and lipoxygenase pathways within the colonic mucosa, decreasing prostaglandin and leukotriene synthesis. This local anti‑inflammatory action reduces neutrophil activation and cytokine release, leading to diminished intestinal inflammation and promotion of mucosal healing.

Side Effects

Mesalazine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Rectal irritation or burning sensation
  • Abdominal pain or cramping
  • Nausea or mild vomiting
  • Headache or dizziness

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, rash, swelling)
  • Blood in stool or severe colitis
  • Elevated liver enzymes or hepatitis
  • Pancreatitis or toxic megacolon

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Renal impairment: monitor renal function regularly.
  • Hepatic impairment: use with caution and assess liver enzymes.
  • Concurrent infection: evaluate risk of worsening infection.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Mesalazine can interact with several medicines; monitor patients accordingly.

Major Interactions (Avoid)

  • Azathioprine: increased risk of bone‑marrow suppression.
  • Methotrexate: additive hepatotoxicity potential.
  • Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in efficacy.
  • NSAIDs: increased gastrointestinal irritation.

Frequently Asked Questions

Mesalazina Eg contains mesalazine, which is prescribed to treat ulcerative colitis and proctitis. It works by reducing inflammation in the colon and rectum, helping to control symptoms such as abdominal pain, diarrhea, and rectal bleeding in patients with inflammatory bowel disease.

Mesalazine inhibits the cyclooxygenase and lipoxygenase pathways in the intestinal lining, decreasing the production of prostaglandins and leukotrienes. This local anti‑inflammatory effect reduces neutrophil activation and cytokine release, leading to less mucosal inflammation and promotion of healing in the colon.

The dosage of Mesalazina Eg is individualized by the prescribing clinician based on disease severity, location, and patient response. The prescriber determines the appropriate amount, frequency, and duration of therapy in accordance with clinical guidelines and patient needs.

Safety data for mesalazine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Mesalazina Eg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mesalazina Eg belongs to the aminosalicylate class, which provides topical anti‑inflammatory action directly in the colon. Compared with systemic steroids or immunomodulators, it generally has a more favorable safety profile but may be less potent for severe disease, making it suitable for mild to moderate ulcerative colitis and proctitis.

Store Mesalazina Eg at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Mesalazina Eg is a rectal formulation intended for local application. It is typically inserted into the rectum using the supplied applicator or enema device, following the instructions provided by the healthcare professional to ensure proper distribution of the medication.

Serious risks include severe allergic reactions such as anaphylaxis, significant gastrointestinal bleeding, hepatitis or marked liver enzyme elevation, pancreatitis, and rare events like toxic megacolon. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, blood in stool, or severe abdominal pain.

Mesalazina Eg should be avoided in patients with known hypersensitivity to mesalazine or other aminosalicylates. Caution is also advised for individuals with severe renal or hepatic impairment, and it is contraindicated in those with active severe infections or a history of hypersensitivity reactions to similar compounds.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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