Product image of Mesalazine Nordic (Mesalazine) supplied by GNH India

Mesalazine Nordic

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazine Nordic (Mesalazine)

Mesalazine, the active ingredient in Mesalazine Nordic, is a 5-aminosalicylic acid (5-ASA) presented as an oral formulation for oral use. It reduces intestinal inflammation and is indicated for ulcerative colitis and colonic Crohn's disease in adult patients.
GNH India supplies Mesalazine Nordic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Nordic Group B.V.

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Indications & Clinical Uses

Mesalazine Nordic belongs to the 5‑ASA class and is used to manage inflammatory bowel disease.

  • Ulcerative colitis: induces and maintains remission by decreasing mucosal inflammation.
  • Crohn's disease (colonic involvement): helps achieve symptom control and mucosal healing in patients with disease limited to the colon.

How It Works

  • Mesalazine acts locally in the gastrointestinal tract where it inhibits cyclooxygenase and lipoxygenase pathways, reducing prostaglandin and leukotriene synthesis. It also modulates cytokine production and interferes with NF‑κB activation, leading to decreased recruitment of inflammatory cells and attenuation of mucosal inflammation.

Side Effects

Mesalazine Nordic may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Abdominal pain or cramping: intermittent discomfort in the lower abdomen.
  • Flatulence: increased intestinal gas.
  • Rash or mild skin irritation.

Serious or Rare Side Effects

  • Pancreatitis: sudden severe abdominal pain with elevated enzymes.
  • Severe liver injury: jaundice, elevated transaminases, or hepatic failure.
  • Blood dyscrasias: neutropenia, anemia, or thrombocytopenia.
  • Severe allergic reaction: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
  • Myocarditis or pericarditis: chest pain with cardiac involvement.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific factors and monitor for potential complications.

  • Renal function: assess baseline creatinine and monitor periodically.
  • Hepatic function: check liver enzymes before and during treatment.
  • Disease severity: ensure appropriate indication and consider alternative therapy for severe disease.
  • Hypersensitivity: avoid in patients with known allergy to mesalazine or related compounds.
  • Concomitant anticoagulants: monitor coagulation parameters due to possible interaction.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Mesalazine can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Azathioprine or 6‑mercaptopurine: heightened risk of myelosuppression.
  • Warfarin: potentiation of anticoagulant effect, increasing bleeding risk.
  • Sulfasalazine: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): possible renal impairment.
  • Oral contraceptives: reduced hormonal efficacy.
  • Diuretics: monitor renal function and electrolyte balance.

Frequently Asked Questions

Mesalazine Nordic is a prescription medication indicated for the treatment of ulcerative colitis and for colonic involvement in Crohn's disease. It helps to induce remission, maintain symptom control, and promote healing of the intestinal lining by reducing local inflammation.

Mesalazine works locally in the gut by inhibiting cyclooxygenase and lipoxygenase enzymes, which lowers prostaglandin and leukotriene production. It also modulates cytokine release and blocks NF‑κB signaling, resulting in reduced recruitment of inflammatory cells and decreased mucosal inflammation.

The prescribed dose of Mesalazine Nordic is individualized by the treating physician based on disease severity, location, and patient response. Dosage adjustments are made according to clinical guidelines and patient tolerance, and patients should follow the prescriber’s instructions exactly.

Safety data for mesalazine in pregnancy and lactation are limited. Clinicians weigh potential benefits against possible risks, and the drug is generally used only if the expected therapeutic advantage justifies exposure. Breastfeeding mothers should discuss potential infant exposure with their healthcare provider.

To order Mesalazine Nordic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mesalazine Nordic delivers the same active moiety as other 5‑ASA products such as sulfasalazine, but it lacks the sulfapyridine component that can cause additional side effects. This often results in a more favorable tolerability profile, especially regarding hypersensitivity reactions, while providing comparable anti‑inflammatory efficacy.

Mesalazine Nordic should be stored at room temperature, below 25 °C, in its original packaging. The container should be kept tightly closed, protected from moisture and direct light, and kept out of reach of children.

The medication is taken orally, usually with a glass of water. It may be swallowed whole or, if a tablet, divided according to the prescriber’s guidance. Doses are typically spaced throughout the day to maintain steady drug levels in the intestine.

Serious adverse events, although rare, include pancreatitis, severe liver injury, blood dyscrasias such as neutropenia or thrombocytopenia, and severe hypersensitivity reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience unexplained abdominal pain, jaundice, unusual bleeding, or skin eruptions.

Mesalazine Nordic is contraindicated in individuals with known hypersensitivity to mesalazine or any component of the formulation. It should also be avoided in patients with severe renal or hepatic impairment unless closely monitored, and in those who have experienced serious adverse reactions to other 5‑ASA agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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