Product image of Mesalazine Teva (Mesalazine) supplied by GNH India

Mesalazine Teva

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazine Teva (Mesalazine)

Mesalazine, the active ingredient in Mesalazine Teva, is a 5-aminosalicylic acid (5-ASA) presented as a tablet for gastroenteral use. It treats ulcerative colitis and Crohn's disease in adult patients by reducing intestinal inflammation.
GNH India supplies Mesalazine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma Belgium N.V./S.A

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Indications & Clinical Uses

Mesalazine Teva belongs to the 5‑ASA class and is used to manage inflammatory bowel disease.

  • Ulcerative colitis: reduces mucosal inflammation and helps maintain clinical remission.
  • Crohn's disease: controls intestinal inflammation and alleviates disease‑related symptoms.
  • Maintenance therapy: supports long‑term disease control after induction of remission.

How It Works

  • Mesalazine releases mesalazine locally in the colon where it inhibits cyclooxygenase and lipoxygenase pathways, decreasing prostaglandin and leukotriene synthesis. It also modulates cytokine production and immune cell activity in the gut mucosa, leading to reduced inflammatory response and promotion of mucosal healing.

Side Effects

Mesalazine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Abdominal pain or cramping
  • Headache
  • Flatulence or bloating
  • Diarrhea
  • Rash or mild skin irritation

Serious or Rare Side Effects

  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia)
  • Hepatotoxicity (elevated liver enzymes, hepatitis)
  • Interstitial nephritis or renal impairment
  • Severe colitis or perforation

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Renal function monitoring: assess baseline creatinine and periodically re‑evaluate.
  • Hepatic function monitoring: check liver enzymes before and during treatment.
  • Hypersensitivity assessment: discontinue if signs of severe allergic reaction appear.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Elderly patients: start at lower doses and monitor closely for toxicity.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mesalazine can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Azathioprine or 6‑mercaptopurine: heightened myelosuppression.
  • Live vaccines: reduced efficacy and potential infection risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.

Frequently Asked Questions

Mesalazine Teva is a 5‑aminosalicylic acid (5‑ASA) medication indicated for the treatment of ulcerative colitis and Crohn's disease. It helps to reduce intestinal inflammation, control symptoms, and maintain remission in adult patients with inflammatory bowel disease.

Mesalazine acts locally in the colon to inhibit cyclooxygenase and lipoxygenase enzymes, decreasing prostaglandin and leukotriene production. It also modulates immune cell activity and cytokine release, which together lower mucosal inflammation and promote healing of the intestinal lining.

The dose of Mesalazine Teva is individualized by the prescribing clinician based on disease severity, location, and patient-specific factors. The healthcare professional determines the appropriate strength, frequency, and duration of therapy for each patient.

Safety data for mesalazine in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Mesalazine belongs to the 5‑ASA class, offering a topical anti‑inflammatory effect in the gut. Compared with sulfasalazine, it has fewer systemic side effects because it does not contain a sulfapyridine moiety. Biologic agents provide systemic immunosuppression and are typically reserved for moderate‑to‑severe disease when 5‑ASA therapy is insufficient.

Mesalazine Teva tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in damp or excessively hot environments.

Mesalazine Teva is taken orally as a tablet. It may be swallowed with a glass of water, with or without food, according to the prescribing clinician’s instructions. Consistent timing each day helps maintain stable drug levels in the colon.

Serious adverse events, although rare, include acute pancreatitis, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, blood dyscrasias (e.g., neutropenia), hepatotoxicity, interstitial nephritis, and severe colitis or intestinal perforation. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, jaundice, rash, or unexplained fever.

Mesalazine Teva is contraindicated in individuals with a known hypersensitivity to mesalazine or any other 5‑ASA compounds. Patients with severe renal impairment, active severe liver disease, or those who have experienced a serious reaction to a similar medication should avoid its use. The prescribing clinician will assess suitability on a case‑by‑case basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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