Product image of Mesalazine Teva (Mesalazine) supplied by GNH India

Mesalazine Teva

Active Ingredient:
Mesalazine
Origin:
EU

Mesalazine Teva (Mesalazine)

Mesalazine, the active ingredient in Mesalazine Teva, is a 5‑aminosalicylic acid (5‑ASA) presented as an oral tablet for oral use. It reduces inflammation in the colon and is employed to manage ulcerative colitis and Crohn’s disease in adult patients. It is indicated for maintenance of remission and induction of response, offering a targeted anti‑inflammatory effect with minimal systemic absorption.

GNH India supplies Mesalazine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics for global healthcare providers.

Manufacturer / TM Owner

Teva Pharma Belgium N.V./S.A

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Indications & Clinical Uses

Mesalazine is a 5‑ASA agent used to treat inflammatory bowel disease by targeting colonic inflammation.

  • Ulcerative colitis: reduces colonic inflammation to induce and maintain remission.
  • Crohn's disease: alleviates intestinal inflammation, helping achieve clinical response.
  • Maintenance therapy: supports long‑term disease control with minimal systemic exposure.

How It Works

  • Mesalazine acts locally in the gastrointestinal tract where it is released as 5‑ASA. It inhibits cyclooxygenase and lipoxygenase pathways, decreasing prostaglandin and leukotriene synthesis, and modulates cytokine production such as interleukin‑1 and tumor necrosis factor‑α, thereby reducing mucosal inflammation without significant systemic absorption.

Side Effects

Mesalazine may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset.
  • Headache: transient headache.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or breathing difficulty.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Kidney impairment: interstitial nephritis or reduced renal function.

Precautions & Warnings

Before initiating therapy, clinicians should consider several precautionary measures.

  • Monitor disease activity: assess clinical response regularly.
  • Assess renal function: check baseline and periodic kidney tests.
  • Evaluate liver enzymes: perform hepatic function tests before and during therapy.
  • Avoid use in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Mesalazine can interact with other medicines; some interactions require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Sulfonamide antibiotics (e.g., trimethoprim‑sulfamethoxazole): heightened risk of hypersensitivity.
  • Live vaccines: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • Azathioprine or 6‑mercaptopurine: potential for enhanced bone marrow suppression.

Frequently Asked Questions

Mesalazine Teva is prescribed to treat inflammatory bowel diseases, specifically ulcerative colitis and Crohn’s disease. It helps reduce inflammation in the colon, supporting both induction of remission and maintenance of disease control in adult patients.

Mesalazine releases 5‑aminosalicylic acid in the gastrointestinal tract where it blocks cyclooxygenase and lipoxygenase enzymes, lowering prostaglandin and leukotriene production. It also modulates cytokines such as interleukin‑1 and TNF‑α, resulting in reduced mucosal inflammation.

The dosage of Mesalazine Teva is individualized. A qualified prescriber determines the appropriate strength, frequency and duration based on the patient’s condition, severity of disease and response to therapy. No generic dosing regimen is provided here.

Safety data for mesalazine during pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss any concerns with the patient. Use only if clearly needed and under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesalazine belongs to the 5‑ASA class, offering a topical anti‑inflammatory effect with minimal systemic exposure. Compared with sulfasalazine, it lacks the sulfapyridine moiety, reducing certain side effects. Biologic agents provide systemic immunomodulation but are typically reserved for moderate‑to‑severe disease when 5‑ASA therapy is insufficient.

Store Mesalazine Teva at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Mesalazine Teva is taken orally as a tablet. It can be swallowed with a glass of water, with or without food, as directed by the prescribing clinician. Patients should follow any specific instructions regarding timing relative to meals.

The most serious adverse events include severe allergic reactions (rash, swelling, breathing difficulty), hepatotoxicity (elevated liver enzymes or jaundice), and kidney impairment such as interstitial nephritis. Patients should seek immediate medical attention if any of these symptoms appear.

Mesalazine should be avoided in individuals with known hypersensitivity to mesalazine or other 5‑ASA compounds. It is also contraindicated in patients with severe renal or hepatic impairment, and caution is advised for those with a history of blood dyscrasias or severe allergic reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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