Product image of Mesalmin Klysmen (Mesalazine) supplied by GNH India

Mesalmin Klysmen

Active Ingredient:
Mesalazine
Origin:
EU

Mesalmin Klysmen (Mesalazine)

Mesalazine, the active ingredient in Mesalmin Klysmen, is an aminosalicylate presented as an unspecified strength/rectal formulation for rectal use. It is used to treat inflammatory bowel conditions such as ulcerative colitis and Crohn's disease involving the colon.

GNH India supplies Mesalmin Klysmen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Falk Pharma G.M.B.H.

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Indications & Clinical Uses

  • Mesalmin Klysmen, a mesalazine‑based aminosalicylate, is employed in the management of inflammatory bowel disease.
  • Ulcerative colitis: reduces mucosal inflammation and helps induce and maintain remission in patients with active disease.
  • Crohn's disease (colonic involvement): controls colonic inflammation and supports maintenance of remission in affected individuals.

How It Works

  • Mesalazine exerts its anti‑inflammatory effect primarily within the colon by inhibiting cyclooxygenase and lipoxygenase pathways, which reduces prostaglandin and leukotriene synthesis. It also modulates local immune responses by decreasing cytokine production and limiting neutrophil activation, thereby lowering intestinal inflammation and promoting mucosal healing.

Side Effects

Mesalmin Klysmen may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Rectal irritation or burning sensation
  • Abdominal pain or cramping
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reaction (rash, swelling, anaphylaxis)
  • Blood in stool or gastrointestinal bleeding
  • Significant liver enzyme elevation or hepatitis

Precautions & Warnings

  • Before initiating Mesalmin Klysmen, several precautionary measures should be considered to ensure safe use.
  • Assess disease severity: confirm active colonic inflammation before therapy.
  • Monitor renal function: periodic serum creatinine and eGFR assessments are recommended.
  • Monitor hepatic function: check liver enzymes regularly during treatment.
  • Avoid concurrent NSAID use: combined therapy may increase risk of renal impairment.
  • Check for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mesalmin Klysmen can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Other 5‑ASA agents (e.g., sulfasalazine, olsalazine): additive toxicity.
  • Live vaccines: reduced efficacy and potential infection risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may exacerbate renal dysfunction.
  • Diuretics: combined use can affect renal clearance of mesalazine.
  • ACE inhibitors or ARBs: monitor renal function when used together.

Frequently Asked Questions

Mesalmin Klysmen is prescribed for inflammatory bowel diseases, specifically ulcerative colitis and Crohn's disease when the colon is involved. It helps reduce intestinal inflammation and supports remission in these chronic conditions.

Mesalazine acts locally in the colon to inhibit cyclooxygenase and lipoxygenase enzymes, decreasing prostaglandin and leukotriene production. It also modulates immune activity by lowering cytokine release and neutrophil activation, which together reduce mucosal inflammation.

The appropriate dose of Mesalmin Klysmen is determined by the prescribing healthcare professional based on disease severity, extent of colonic involvement, and individual patient factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for mesalazine in pregnancy and lactation are limited. The prescriber will weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To order, submit an enquiry on the Mesalmin Klysmen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesalmin Klysmen delivers mesalazine directly to the colon via a rectal formulation, which can provide higher local concentrations than oral 5‑ASA agents. This route may be advantageous for distal disease but requires patient acceptance of rectal administration. Efficacy and safety are comparable when used appropriately.

Store Mesalmin Klysmen at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, excessive heat and direct sunlight to maintain product stability.

Mesalmin Klysmen is administered rectally, typically as an enema or suppository, according to the prescriber’s instructions. The patient should retain the dose for the recommended time to allow optimal drug contact with the colonic mucosa.

Serious risks include severe allergic reactions such as rash, swelling or anaphylaxis, gastrointestinal bleeding, and significant liver enzyme elevations indicating possible hepatitis. Any of these symptoms require immediate medical attention.

Patients with known hypersensitivity to mesalazine or any component of the formulation should avoid use. Caution is also advised for individuals with severe renal or hepatic impairment, and those taking interacting medications without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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