Product image of Mesar (Olmesartan Medoxomil) supplied by GNH India

Mesar

Active Ingredient:
Olmesartan Medoxomil
Origin:
EU

Mesar (Olmesartan Medoxomil)

Olmesartan medoxomil, the active ingredient in Mesar, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral administration. It is indicated for the management of hypertension in adult patients, helping to lower elevated blood pressure and reduce cardiovascular risk.

GNH India supplies Mesar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured antihypertensive medication.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Olmesartan medoxomil is an ARB used to treat conditions related to the renin‑angiotensin system, primarily hypertension.

  • Hypertension: lowers systolic and diastolic blood pressure in patients with essential hypertension.
  • High blood pressure: assists in achieving target blood pressure levels as part of antihypertensive therapy.
  • Cardiovascular risk management: contributes to risk reduction by controlling blood pressure in at‑risk adults.

How It Works

  • Olmesartan medoxomil selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from binding. This inhibition reduces vasoconstriction, aldosterone secretion, and sympathetic activation, leading to relaxation of vascular smooth muscle and decreased peripheral resistance, which lowers blood pressure.

Side Effects

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: feeling unusually tired or weak.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nasal congestion: blocked or runny nose.
  • Back pain: soreness in the lower back.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue, or throat that may impair breathing.
  • Hyperkalemia: elevated potassium levels that can affect heart rhythm.
  • Acute renal failure: sudden loss of kidney function.
  • Severe hypotension: markedly low blood pressure causing faintness.
  • Liver injury: abnormal liver function tests or hepatitis.
  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.

Precautions & Warnings

Olmesartan medoxomil should be used with caution in specific clinical situations.

  • Pregnancy: contraindicated in pregnancy (Category D) due to risk of fetal toxicity.
  • Renal impairment: monitor kidney function and adjust therapy as needed.
  • Hepatic impairment: use with caution; assess liver enzymes periodically.
  • Electrolyte imbalance: watch for hyperkalemia, especially when combined with potassium‑sparing agents.
  • Concomitant aliskiren in diabetes: avoid combined use due to increased risk of renal complications.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Olmesartan medoxomil may interact with several medicines; monitoring is essential.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: combined use can increase renal risk.
  • Dual therapy with ACE inhibitors or other ARBs: may cause excessive hypotension and renal dysfunction.
  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive efficacy and affect renal function.
  • Lithium: can increase lithium serum concentrations, risking toxicity.
  • Thiazide diuretics: may enhance hypotensive effect; monitor blood pressure closely.

Frequently Asked Questions

Mesar contains olmesartan medoxomil, an angiotensin II receptor blocker indicated for the treatment of hypertension in adult patients. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular events associated with high blood pressure.

Olmesartan medoxomil selectively blocks the AT1 receptor for angiotensin II, preventing vasoconstriction and aldosterone release. This leads to relaxation of blood vessels, reduced peripheral resistance, and ultimately a decrease in blood pressure.

The appropriate dose of Mesar is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Mesar is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should not be used during pregnancy. Limited data are available for breastfeeding; therefore, use is generally discouraged unless the benefit outweighs the potential risk.

To order Mesar, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mesar (olmesartan) belongs to the ARB class, offering blood‑pressure control similar to ACE inhibitors but with a lower incidence of cough. Compared with other ARBs, olmesartan provides once‑daily dosing and a favorable tolerability profile, making it a common choice for patients who cannot tolerate ACE inhibitors.

Mesar should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Mesar is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include angioedema (swelling of the face, lips, tongue, or throat), severe hypotension, hyperkalemia (high potassium levels), and acute renal impairment. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, sudden dizziness, or signs of kidney dysfunction.

Mesar should not be used by pregnant women, individuals with known hypersensitivity to olmesartan or any component of the formulation, and patients with severe hepatic impairment. Caution is also advised for those with significant renal dysfunction or electrolyte abnormalities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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