Product image of Mesar Plus (Olmesartan Medoxomil, Hydrochlorothiazide) supplied by GNH India

Mesar Plus

Active Ingredient:
Olmesartan Medoxomil, Hydrochlorothiazide
Origin:
EU

Mesar Plus (Olmesartan Medoxomil, Hydrochlorothiazide)

Olmesartan medoxomil and hydrochlorothiazide, the active ingredients in Mesar Plus, are an Angiotensin II receptor blocker (ARB) and a thiazide diuretic presented as an oral tablet for oral use. They work together to lower elevated blood pressure in adult patients with hypertension.

GNH India supplies Mesar Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union regulatory standards and is manufactured under GMP conditions. It is distributed through a validated logistics network to ensure product integrity during global shipment.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Mesar Plus, a combination of an ARB and a thiazide diuretic, is indicated for the management of hypertension.

  • Essential hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Secondary hypertension: assists in blood pressure control when hypertension is due to renal or endocrine causes.

How It Works

  • Olmesartan medoxomil selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes. The combined actions decrease peripheral vascular resistance and plasma volume, resulting in a sustained reduction of arterial blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Increased frequency of urination due to the diuretic effect.
  • Mild headache or fatigue.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema).
  • Significant electrolyte disturbances such as hyponatremia or hypokalemia.
  • Acute kidney injury or worsening renal function.
  • Persistent low blood pressure (hypotension) leading to fainting.
  • Pancreatitis or severe liver injury (very rare).

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure regularly to ensure adequate control.
  • Assess renal function and serum electrolytes, especially potassium and sodium levels.
  • Adjust dose or discontinue if significant dehydration or electrolyte imbalance occurs.
  • Use with caution in patients with severe hepatic impairment.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mesar Plus may interact with several medicines. Review patient medication lists carefully.

Major Interactions (Avoid)

  • Lithium: risk of lithium toxicity due to reduced renal clearance.
  • Potassium‑sparing diuretics or supplements: may cause hyperkalemia.
  • ACE inhibitors or aliskiren in diabetic patients: increased risk of renal impairment.
  • NSAIDs (high‑dose or chronic use): may blunt antihypertensive effect and affect kidney function.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives (beta‑blockers, calcium channel blockers): may enhance blood pressure lowering.
  • Diuretics other than thiazides: monitor electrolytes and volume status.
  • Antidiabetic agents: blood glucose may improve, requiring dose adjustment.
  • Digoxin: increased risk of digoxin toxicity in the setting of electrolyte disturbances.

Frequently Asked Questions

Mesar Plus is a prescription oral tablet that combines olmesartan medoxomil, an angiotensin II receptor blocker, with hydrochlorothiazide, a thiazide diuretic. The combination is used to treat high blood pressure (hypertension) in adult patients, helping to lower both systolic and diastolic pressures and reduce cardiovascular risk.

Olmesartan medoxomil selectively blocks AT1 receptors, which are the primary binding sites for angiotensin II. By preventing angiotensin II from activating these receptors, the drug reduces vasoconstriction and aldosterone secretion, leading to relaxed blood vessels and lower blood pressure.

The dosage of Mesar Plus is determined by the prescribing healthcare professional based on the individual’s blood pressure, response to therapy, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of Mesar Plus in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and it is generally avoided unless clearly needed.

To order Mesar Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mesar Plus combines an ARB with a thiazide diuretic, offering dual mechanisms—vascular relaxation and volume reduction—in a single tablet. Compared with monotherapy, this can improve blood pressure control and simplify dosing, while avoiding the cough associated with ACE inhibitors and providing a predictable diuretic effect.

Mesar Plus should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablet container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Mesar Plus is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a full glass of water and do not crush or chew it.

Serious risks include severe allergic reactions (anaphylaxis, angioedema), significant electrolyte disturbances (especially low potassium or sodium), acute kidney injury, and marked hypotension that can cause fainting. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, severe dizziness, or sudden loss of kidney function.

Mesar Plus is contraindicated in patients with known hypersensitivity to olmesartan, hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, anuria, or those who are pregnant unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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