Product image of Mesiglic (Metformin Hydrochloride, Sitagliptin) supplied by GNH India

Mesiglic

Active Ingredient:
Metformin Hydrochloride, Sitagliptin
Origin:
EU

Mesiglic (Metformin Hydrochloride, Sitagliptin)

Metformin Hydrochloride / Sitagliptin, the active ingredient in Mesiglic, is a Biguanide; DPP‑4 inhibitor presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adults.
GNH India supplies Mesiglic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratório Medinfar - Produtos Farmacêuticos, S.A.

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Indications & Clinical Uses

Mesiglic is used to improve glycaemic control in patients with type 2 diabetes mellitus, acting on multiple pathways of glucose regulation.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels.
  • Adjunct to diet and exercise: enhances the effectiveness of lifestyle interventions.
  • Combination therapy with other antidiabetics: provides additional glucose‑lowering benefit when used with insulin or other oral agents.

How It Works

  • Metformin reduces hepatic gluconeogenesis and increases peripheral insulin sensitivity, while Sitagliptin inhibits dipeptidyl peptidase‑4, prolonging the activity of endogenous incretins (GLP‑1 and GIP). The combined actions enhance glucose‑dependent insulin secretion, suppress glucagon release, and improve overall glycaemic control.

Side Effects

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhea.
  • Headache: mild to moderate intensity.
  • Mild hypoglycaemia: especially when combined with insulin or sulfonylureas.
  • Metallic taste: transient alteration in taste perception.
  • Weight loss: modest reduction observed in some patients.

Serious or Rare Side Effects

  • Lactic acidosis: potentially fatal metabolic disturbance.
  • Severe hypoglycaemia: marked low blood glucose requiring medical intervention.
  • Pancreatitis: inflammation of the pancreas.
  • Hepatic dysfunction: elevated liver enzymes or liver injury.
  • Allergic reactions: rash, pruritus, or angio‑edema.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, evaluate patient-specific factors and monitor for adverse events.

  • Renal function: assess creatinine clearance and avoid use in severe renal impairment.
  • Hepatic impairment: use with caution; monitor liver enzymes.
  • Risk of lactic acidosis: avoid in conditions predisposing to hypoxia or tissue hypoperfusion.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare professional.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mesiglic may interact with several medicines; clinical judgment is required.

Major Interactions (Avoid)

  • Iodinated contrast media: increased risk of renal dysfunction and lactic acidosis.
  • Alcohol: potentiates metformin‑related lactic acidosis.
  • Cimetidine: may raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: can mask symptoms of hypoglycaemia.
  • Diuretics: may affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and electrolytes during combined use.

Frequently Asked Questions

Mesiglic is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus, either as monotherapy or in combination with other antidiabetic agents.

Metformin decreases hepatic glucose production and enhances insulin sensitivity, while Sitagliptin blocks the DPP‑4 enzyme, prolonging incretin activity that stimulates insulin release and reduces glucagon secretion.

The specific dose and dosing schedule are determined by the prescribing clinician based on individual patient factors such as renal function, glycaemic targets, and concomitant therapies.

Safety of Metformin Hydrochloride / Sitagliptin in pregnancy and lactation has not been fully established. Use only if the potential benefit justifies the potential risk and after consultation with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesiglic combines a biguanide (metformin) and a DPP‑4 inhibitor (sitagliptin) in one tablet, offering dual mechanisms of action. This can provide greater glucose lowering than metformin alone and avoids the injectable route required for some GLP‑1 analogues.

Store Mesiglic at ambient temperature, below 25 °C, in the original packaging. Protect the tablets from moisture, heat and direct sunlight to maintain stability.

Mesiglic is taken orally, usually with meals to reduce gastrointestinal discomfort. Swallow the tablet whole with a glass of water; do not crush or chew unless instructed by a healthcare provider.

The most serious risks include lactic acidosis, severe hypoglycaemia (especially when combined with insulin or sulfonylureas), pancreatitis, and rare severe skin reactions such as Stevens‑Johnson syndrome.

Mesiglic should be avoided in patients with severe renal impairment, known hypersensitivity to metformin or sitagliptin, active liver disease, or a history of lactic acidosis. Clinicians should also assess risk before prescribing to patients with unstable heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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