Product image of Mesiproc (Clopidogrel) supplied by GNH India

Mesiproc

Active Ingredient:
Clopidogrel
Origin:
EU

Mesiproc (Clopidogrel)

Clopidogrel, the active ingredient in Mesiproc, is an antiplatelet agent presented as an oral tablet for oral use. It helps prevent atherothrombotic events in patients with acute coronary syndrome, myocardial infarction, ischemic stroke or peripheral arterial disease.
GNH India supplies Mesiproc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Farmacêutica Lda.

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Indications & Clinical Uses

Mesiproc, a P2Y12 receptor antagonist, is employed in several cardiovascular and cerebrovascular conditions.

  • Acute coronary syndrome: reduces the risk of recurrent myocardial infarction and death.
  • Post‑myocardial infarction (secondary prevention): lowers incidence of further cardiac events.
  • Ischemic stroke or transient ischemic attack: prevents recurrent stroke.
  • Peripheral arterial disease: diminishes limb‑related ischemic complications.

How It Works

  • Clopidogrel is an irreversible antagonist of the platelet P2Y12 ADP receptor. By binding covalently to the receptor, it blocks ADP‑mediated activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation and thrombus formation in arterial circulation.

Side Effects

Clopidogrel may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bleeding gums
  • Easy bruising
  • Nausea
  • Diarrhea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Severe or uncontrolled bleeding
  • Thrombotic thrombocytopenic purpura
  • Significant liver enzyme elevation
  • Allergic reactions including anaphylaxis

Precautions & Warnings

When prescribing Mesiproc, clinicians should consider several safety measures.

  • Bleeding risk: evaluate patient history of hemorrhage before initiation.
  • Surgical procedures: discontinue according to peri‑operative guidelines.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Concomitant anticoagulants: be aware of additive bleeding risk.
  • Drug hypersensitivity: avoid in patients with known clopidogrel allergy.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Clopidogrel interacts with several drug classes that may modify its antiplatelet effect or increase bleeding.

Major Interactions (Avoid)

  • Warfarin: synergistic increase in bleeding risk.
  • NSAIDs (e.g., ibuprofen, naproxen): heightened hemorrhage potential.
  • SSRIs or SNRIs: additive bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors (omeprazole, esomeprazole): may reduce clopidogrel activation.
  • CYP2C19 inhibitors (fluconazole, ticagrelor): alter metabolic conversion.
  • ACE inhibitors: monitor renal function and electrolytes.

Frequently Asked Questions

Mesiproc contains clopidogrel, an antiplatelet medication used to reduce the risk of atherothrombotic events in acute coronary syndrome, after myocardial infarction, in patients with a history of ischemic stroke or transient ischemic attack, and in peripheral arterial disease.

Clopidogrel irreversibly blocks the platelet P2Y12 ADP receptor, preventing ADP‑induced activation of the glycoprotein IIb/IIIa complex. This inhibition stops platelets from aggregating, thereby reducing the formation of arterial clots.

The dosage of Mesiproc is determined by the prescribing clinician based on the individual patient's clinical condition, renal function, and concomitant therapies. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for clopidogrel in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician.

To request Mesiproc, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesiproc (clopidogrel) is a P2Y12 receptor antagonist, similar to ticagrelor and prasugrel. Unlike ticagrelor, clopidogrel requires metabolic activation and has a longer onset of action, while prasugrel may have a higher bleeding risk in certain populations. Choice of therapy depends on patient risk profile and physician judgment.

Mesiproc should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and out of reach of children.

Mesiproc is taken orally, usually as a whole tablet with or without food. Patients should swallow the tablet whole and avoid crushing or chewing it unless otherwise instructed by a healthcare professional.

The most serious risks include severe or uncontrolled bleeding, thrombotic thrombocytopenic purpura, and rare allergic reactions such as anaphylaxis. Patients should be educated to report any unusual bleeding, bruising, or signs of hypersensitivity promptly.

Mesiproc is contraindicated in patients with active pathological bleeding, known hypersensitivity to clopidogrel or any component of the formulation, and in individuals who have had a recent intracranial hemorrhage. Clinicians should also exercise caution in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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