Product image of Mesna Eg (Mesna) supplied by GNH India

Mesna Eg

Active Ingredient:
Mesna
Origin:
EU

Mesna Eg (Mesna)

Mesna, the active ingredient in Mesna Eg, is a thiol‑containing chemoprotective agent presented as an intravenous solution for intravenous use. It is employed to protect the bladder from toxic metabolites generated during certain chemotherapy regimens.
GNH India supplies Mesna Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Eg Labo Laboratoires Eurogenerics

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Indications & Clinical Uses

Mesna is used to protect the urinary tract during chemotherapy that produces acrolein, a urotoxic metabolite.

  • Hemorrhagic cystitis caused by cyclophosphamide: prevents bladder toxicity and bleeding.
  • Hemorrhagic cystitis caused by ifosfamide: reduces risk of bladder irritation and hemorrhage.
  • Acrolein‑mediated bladder toxicity: provides uroprotection during high‑dose alkylating agent therapy.

How It Works

  • Mesna contains a sulfhydryl group that rapidly binds to acrolein, the toxic metabolite formed from cyclophosphamide and ifosfamide. By forming a stable, non‑reactive complex, Mesna neutralizes acrolein in the urinary tract, thereby preventing its damaging effects on the bladder epithelium.

Side Effects

Mesna is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea or vomiting.
  • Mild headache.
  • Transient hypotension.
  • Metallic taste in the mouth.
  • Mild skin rash.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Hemolysis in patients with G6PD deficiency.
  • Severe hypotension or shock.
  • Pulmonary edema.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Acute renal failure.

Precautions & Warnings

Mesna should be used with attention to the following safety considerations.

  • Renal function: monitor urine output and renal parameters during therapy.
  • G6PD deficiency: avoid use because of risk of hemolysis.
  • Concurrent chemotherapy: coordinate timing with cyclophosphamide or ifosfamide administration.
  • Allergy: discontinue immediately if signs of hypersensitivity appear.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus (category unknown).
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mesna may interact with other agents that affect oxidative balance or renal clearance.

Major Interactions (Avoid)

  • Co‑administration with high‑dose methylene blue: may reduce Mesna’s protective effect.
  • Use with nephrotoxic drugs in patients with severe renal impairment: may increase Mesna accumulation.

Moderate Interactions (Monitor Closely)

  • Concurrent thiol‑containing agents (e.g., N‑acetylcysteine): may increase risk of adverse reactions.
  • High‑dose vitamin C supplementation: could interfere with acrolein binding.
  • Loop diuretics: may alter urinary excretion of Mesna and require dose adjustment.

Frequently Asked Questions

Mesna Eg is used as a uroprotective agent to prevent hemorrhagic cystitis that can occur during treatment with the chemotherapy drugs cyclophosphamide or ifosfamide. It works by neutralising the toxic metabolite acrolein, thereby protecting the bladder lining.

Mesna contains a sulfhydryl (‑SH) group that binds directly to acrolein, the harmful by‑product of cyclophosphamide and ifosfamide metabolism. This binding forms a non‑reactive complex that is safely excreted in urine, preventing acrolein from damaging the bladder epithelium.

The dose of Mesna Eg is determined by the prescribing physician based on the specific chemotherapy regimen, patient weight, renal function and treatment schedule. Only a qualified healthcare professional should set the dosing and administration plan.

The pregnancy category for Mesna is unknown, and safety data are limited. It should only be used during pregnancy if the potential benefit outweighs the potential risk to the fetus. Breastfeeding is not recommended unless the prescriber determines it is safe.

To order Mesna Eg, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mesna is the most widely used thiol‑containing agent specifically designed to inactivate acrolein. Unlike some generic antioxidants, Mesna directly binds the toxic metabolite, offering a targeted and predictable protective effect during cyclophosphamide or ifosfamide therapy.

Mesna Eg should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. If the product reaches room temperature, it may be used within the time frame specified by the manufacturer.

Mesna Eg is supplied as an intravenous solution and is administered by a healthcare professional through a vein, usually shortly before, during, or after the chemotherapy infusion, according to the treatment protocol established by the oncologist.

The most serious risks include severe allergic reactions such as anaphylaxis, hemolysis in patients with glucose‑6‑phosphate dehydrogenase deficiency, and rare cases of severe hypotension or pulmonary edema. Prompt medical attention is required if any of these occur.

Mesna Eg should not be used in patients known to be hypersensitive to Mesna or any of its excipients, and it is contraindicated in individuals with G6PD deficiency due to the risk of hemolysis. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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