Product image of Mestane (Exemestane) supplied by GNH India

Mestane

Active Ingredient:
Exemestane
Origin:
EU

Mestane (Exemestane)

Exemestane, the active ingredient in Mestane, is a aromatase inhibitor presented as an oral tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women.
GNH India supplies Mestane as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Sophos Biotech Srl

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Indications & Clinical Uses

Exemestane acts on the estrogen‑dependent pathway of hormone‑sensitive breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces risk of disease recurrence after surgery.
  • Advanced/metastatic breast cancer (postmenopausal): Provides disease control when combined with other hormonal agents.
  • Adjuvant endocrine therapy: Complements other treatments to improve overall survival.

How It Works

  • Exemestane irreversibly binds to the aromatase enzyme, permanently inactivating it and preventing the conversion of androgens to estrogens. This leads to a marked reduction in circulating estrogen levels, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby inhibiting tumor proliferation.

Side Effects

Exemestane may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Joint and muscle pain: Arthralgia or myalgia.
  • Fatigue: Persistent tiredness.
  • Nausea: Mild to moderate upset stomach.
  • Headache: Tension‑type or migraine‑like.
  • Dizziness: Light‑headed sensation.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism: Blood clots in veins or lungs.
  • Severe liver injury: Elevated transaminases or hepatitis.
  • Bone fractures: Increased risk due to lowered estrogen.
  • Myocardial infarction: Heart attack events.
  • Severe allergic reactions: Anaphylaxis or angioedema.
  • Hyperglycemia: Elevated blood sugar levels.

Precautions & Warnings

Before initiating Exemestane therapy, several safety considerations are recommended.

  • Bone health monitoring: Assess bone mineral density periodically.
  • Liver function assessment: Perform baseline and periodic liver enzyme tests.
  • Cardiovascular risk evaluation: Review history of thromboembolic events.
  • Avoid use in premenopausal women: Not indicated for this population.
  • Review concomitant hormone therapy: Ensure no estrogen supplementation.
  • Store at below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Exemestane can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Estrogen‑containing products: Counteracts aromatase inhibition.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase Exemestane exposure.
  • Strong CYP3A4 inducers (e.g., rifampin): May reduce therapeutic effect.
  • Tamoxifen: Antagonistic hormonal actions.
  • Warfarin: Potential alteration of anticoagulant control.

Moderate Interactions (Monitor Closely)

  • SSRIs (e.g., fluoxetine): May affect hormone levels.
  • Statins (e.g., simvastatin): Possible increased risk of muscle toxicity.
  • Glucocorticoids: May influence bone health.
  • Antihypertensives: Monitor blood pressure changes.
  • Bisphosphonates: Coordinate bone‑protective strategies.

Frequently Asked Questions

Mestane contains the active ingredient exemestane and is used to treat hormone receptor‑positive breast cancer in postmenopausal women, both as adjuvant therapy after surgery and for advanced disease control.

Exemestane irreversibly inhibits the aromatase enzyme, blocking the conversion of androgens to estrogens. This lowers estrogen levels in the body, depriving estrogen‑dependent tumor cells of a key growth signal.

The prescribed dose of Mestane is determined by the treating physician based on the patient’s clinical condition, treatment setting, and regulatory guidelines. Patients should follow the prescriber’s instructions exactly.

Exemestane is contraindicated in pregnancy and is not recommended for breastfeeding women because it can affect estrogen levels. Women of child‑bearing potential should use effective contraception during treatment.

To order Mestane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Mestane (exemestane) is a steroidal, irreversible aromatase inhibitor, whereas agents like letrozole and anastrozole are non‑steroidal and reversible. The irreversible binding of exemestane may offer a different safety and efficacy profile, particularly regarding bone health and lipid metabolism.

Mestane tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.

Mestane is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with water; do not crush or split unless instructed.

Serious risks include deep vein thrombosis, pulmonary embolism, severe liver injury, bone fractures, myocardial infarction, and severe allergic reactions. Patients should be monitored regularly for signs of these events.

Mestane should not be used by premenopausal women, pregnant or nursing mothers, patients with severe liver impairment, or individuals with a history of thromboembolic disorders unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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