Product image of Mestinon 60 (Pyridostigmine Bromide) supplied by GNH India

Mestinon 60

Active Ingredient:
Pyridostigmine Bromide
Origin:
EU

Mestinon 60 (Pyridostigmine Bromide)

Pyridostigmine bromide, the active ingredient in Mestinon 60, is a cholinesterase inhibitor presented as a 60 mg tablet for oral use. It treats myasthenia gravis by improving neuromuscular transmission in affected patients.

GNH India supplies Mestinon 60 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Gmbh

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Indications & Clinical Uses

  • Mestinon 60, a cholinesterase inhibitor, is used primarily in disorders of neuromuscular transmission.
  • Myasthenia gravis: improves overall muscle strength and reduces fatigue.
  • Ocular myasthenia: alleviates eye‑muscle weakness and double vision.
  • Post‑operative residual neuromuscular blockade: helps reverse non‑depolarizing muscle relaxant effects.

How It Works

  • Pyridostigmine bromide reversibly inhibits acetylcholinesterase at the neuromuscular junction, preventing the breakdown of acetylcholine. The resulting increase in acetylcholine concentration enhances stimulation of nicotinic receptors on skeletal muscle, thereby improving muscle contraction and reducing the weakness characteristic of myasthenic disorders.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: increased bowel movements.
  • Excessive salivation: watery mouth.
  • Sweating: heightened perspiration.
  • Muscle cramps: intermittent tightening.

Serious or Rare Side Effects

  • Bradycardia: unusually slow heart rate.
  • Cholinergic crisis: severe muscle weakness and respiratory difficulty.
  • Allergic reactions: rash, itching, or angioedema.
  • Respiratory depression: reduced breathing effort.
  • Seizures: rare convulsive episodes.

Precautions & Warnings

Mestinon 60 should be used with attention to patient‑specific factors and potential risks.

  • Renal impairment: adjust dose because the drug is renally excreted.
  • Asthma or COPD: monitor for bronchospasm due to increased secretions.
  • Concomitant anticholinergics: avoid antagonistic effects.
  • Pregnancy: safety not established; weigh benefits against risks.
  • Storage: Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Pyridostigmine bromide may interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticholinergic agents (e.g., atropine): block therapeutic effect.
  • Succinylcholine: prolonged neuromuscular blockade.
  • Aminoglycoside antibiotics: potentiate neuromuscular weakness.

Moderate Interactions (Monitor Closely)

  • Non‑depolarizing muscle relaxants: may enhance muscle weakness.
  • Beta‑blockers: possible additive bradycardia.
  • Cardiac glycosides (e.g., digoxin): monitor for arrhythmias.

Frequently Asked Questions

Mestinon 60 contains pyridostigmine bromide, a cholinesterase inhibitor prescribed to improve muscle strength in patients with myasthenia gravis and related neuromuscular transmission disorders.

The drug reversibly blocks acetylcholinesterase, the enzyme that degrades acetylcholine. By raising acetylcholine levels at the neuromuscular junction, it enhances stimulation of muscle receptors and reduces weakness.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s condition, severity, and response to therapy. Patients should follow the prescriber’s instructions precisely.

Safety data for pyridostigmine bromide in pregnancy and lactation are limited. The prescriber must evaluate potential benefits against possible risks before recommending use in pregnant or nursing individuals.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mestinon 60 is a symptomatic oral agent that increases acetylcholine levels, whereas immunosuppressants and monoclonal antibodies target the underlying autoimmune process. Choice of therapy depends on disease severity, patient tolerance and physician judgment.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Mestinon 60 is taken orally, usually with water. It may be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals to optimize absorption.

Serious risks include cholinergic crisis, which can cause severe muscle weakness and respiratory failure, as well as bradycardia, allergic reactions such as rash or angioedema, and, rarely, seizures. Immediate medical attention is required if these occur.

Patients with known hypersensitivity to pyridostigmine bromide or any tablet excipients should avoid the product. Caution is also advised for individuals with severe renal impairment, uncontrolled asthma, or those taking contraindicated medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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