Metadon (Methadone Hydrochloride)

Methadone is a full agonist at the µ‑opioid receptor, providing analgesia and suppressing withdrawal by replacing the opioid effect. It also blocks NMDA receptors and inhibits serotonin and norepinephrine reuptake, which helps control pain and reduces hyperalgesia.

The appropriate dose of Metadon is individualized by the prescribing clinician based on the patient’s opioid use history, treatment goals, response, and tolerability. Dosage adjustments are made under medical supervision.

Methadone is classified as Pregnancy Category C, meaning risk cannot be ruled out. It may be used if the potential benefit justifies the risk. Methadone does pass into breast milk, so breastfeeding decisions should be made with a healthcare professional.

To order Metadon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both methadone (Metadon) and buprenorphine are used for opioid dependence, but methadone is a full µ‑opioid agonist offering stronger analgesia, while buprenorphine is a partial agonist with a ceiling effect that reduces overdose risk. Choice depends on patient history, treatment setting and clinician judgment.

Metadon should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Metadon is administered orally, typically as a tablet taken with water. The exact dosing schedule—once daily or divided doses—depends on the prescribing clinician’s plan and the patient’s clinical response.

The most serious risks include respiratory depression, especially when combined with other central nervous system depressants, cardiac arrhythmias such as QT prolongation, and severe hypotension. Prompt medical attention is required if any of these events occur.

Metadon is contraindicated in patients with known hypersensitivity to methadone, those with severe respiratory insufficiency, uncontrolled cardiac arrhythmias, or who are currently taking monoamine oxidase inhibitors. Caution is also advised for individuals with significant liver impairment.