Product image of Metafen (Dexketoprofen) supplied by GNH India

Metafen

Active Ingredient:
Dexketoprofen
Origin:
EU

Metafen (Dexketoprofen)

Dexketoprofen, the active ingredient in Metafen, is a nonsteroidal anti‑inflammatory drug presented as an oral formulation for systemic use. It is indicated for the relief of mild to moderate acute pain, including musculoskeletal, dental, post‑operative and dysmenorrhea pain. It belongs to the ketoprofen class and provides rapid onset of analgesia, typically within 30 minutes after ingestion.

GNH India supplies Metafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Dexketoprofen acts as an NSAID to alleviate pain and inflammation in several acute conditions.
  • Mild to moderate acute pain: provides analgesic relief for short‑term pain episodes.
  • Musculoskeletal pain: reduces inflammation and improves mobility.
  • Dental pain: eases postoperative discomfort after dental procedures.
  • Post‑operative pain: controls pain following surgery.
  • Dysmenorrhea: alleviates menstrual cramps and associated discomfort.

How It Works

  • Dexketoprofen inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, leading to a reduction in prostaglandin synthesis. This decrease in prostaglandins diminishes the inflammatory response, lowers fever, and provides analgesic effects by interrupting the biochemical pathways that generate pain signals.

Side Effects

Dexketoprofen may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea or upset stomach.
  • Dyspepsia or heartburn.
  • Headache.
  • Dizziness.
  • Mild increase in blood pressure.
  • Transient renal function changes.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe renal impairment.
  • Anaphylactic or severe hypersensitivity reactions.
  • Hepatic failure or significant liver enzyme elevation.
  • Cardiovascular events such as myocardial infarction or stroke.
  • Severe skin reactions including Stevens‑Johnson syndrome.

Precautions & Warnings

  • When prescribing or dispensing Metafen, consider the following safety measures.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Monitor hepatic function: exercise caution in liver disease.
  • Avoid in known NSAID hypersensitivity: contraindicated for patients with previous allergic reactions.
  • Use with caution in cardiovascular disease: monitor blood pressure and heart status.
  • Use with caution in the elderly: increased risk of gastrointestinal and renal side effects.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Dexketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: heightened lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, ARBs): may reduce blood pressure control.
  • Diuretics: potential for reduced renal perfusion.
  • Corticosteroids: increased risk of gastrointestinal ulceration.
  • Methotrexate: possible elevation of methotrexate levels.
  • Cyclosporine: may increase nephrotoxicity risk.

Frequently Asked Questions

Metafen contains dexketoprofen, an NSAID indicated for relief of mild‑to‑moderate acute pain such as musculoskeletal, dental, post‑operative and dysmenorrhea. It provides both analgesic and anti‑inflammatory effects to improve patient comfort during short‑term pain episodes.

Dexketoprofen blocks cyclooxygenase‑1 and‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels diminish inflammation, fever, and the transmission of pain signals, resulting in rapid analgesia and anti‑inflammatory activity.

The dosage of Metafen is determined by the prescribing clinician based on the patient’s age, weight, pain severity, and renal or hepatic status. The prescriber selects the appropriate strength and dosing interval according to local labeling and clinical guidelines.

Safety of dexketoprofen during pregnancy and lactation has not been fully established. It should only be used if the potential benefit outweighs the possible risk to the fetus or infant, and only under direct medical supervision.

To place an order, submit an enquiry on the Metafen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Dexketoprofen is the S‑enantiomer of ketoprofen, offering a faster onset of pain relief and potentially lower gastrointestinal irritation compared with racemic ketoprofen. Compared with ibuprofen or naproxen, it provides comparable efficacy but may be preferred when rapid analgesia is needed.

Metafen should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Avoid storing in humid areas such as bathrooms or near heat sources.

Metafen is taken orally, usually with a full glass of water. It may be taken with or without food; taking it with food can lessen occasional stomach discomfort. Swallow the tablet whole and do not crush or chew unless directed by a healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hypersensitivity reactions such as anaphylaxis, and cardiovascular events in susceptible patients. Immediate medical attention is required if signs of serious bleeding, rash, or sudden kidney problems appear.

Metafen should be avoided in patients with known hypersensitivity to dexketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and those with significant renal or hepatic impairment unless closely monitored by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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