Product image of Metafen Forte (Ibuprofen Lysine) supplied by GNH India

Metafen Forte

Active Ingredient:
Ibuprofen Lysine
Origin:
EU

Metafen Forte (Ibuprofen Lysine)

Ibuprofen lysine, the active ingredient in Metafen Forte, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for external use. It relieves musculoskeletal pain, inflammation and sports‑related injuries in adults.

GNH India supplies Metafen Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

  • Ibuprofen lysine, a topical NSAID, is used to manage conditions involving inflammation and pain in the musculoskeletal system.
  • Musculoskeletal pain: provides localized relief of pain in muscles and joints.
  • Inflammation: reduces swelling and redness at the site of injury.
  • Sports‑related injuries: helps alleviate pain and inflammation from sprains, strains and overuse.

How It Works

  • Ibuprofen lysine exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes in peripheral tissues. This inhibition lowers prostaglandin synthesis, which diminishes the inflammatory cascade and reduces the perception of pain at the site of application.

Side Effects

Topical ibuprofen lysine can cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects

  • Local skin irritation or redness at the application site.
  • Itching or mild burning sensation.
  • Dryness or peeling of the skin.
  • Pruritus (itchy skin).
  • Mild erythema.

Serious or Rare Side Effects

  • Allergic dermatitis or severe skin rash.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic gastrointestinal ulceration or bleeding.
  • Acute renal impairment.
  • Hepatic dysfunction.
  • Anaphylactic reaction.

Precautions & Warnings

  • When using topical ibuprofen lysine, consider the following safety measures.
  • Assess skin integrity: avoid application on broken, infected or irritated skin.
  • Limit area: apply to no more than 10 % of body surface at a time.
  • Avoid occlusion: do not cover the treated area with airtight dressings.
  • Monitor for systemic absorption: use caution in patients with renal or hepatic disease.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Topical ibuprofen lysine may interact with systemic medications; awareness of major and moderate interactions is important.

Major Interactions (Avoid)

  • Concurrent systemic NSAIDs: increased risk of systemic adverse effects.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Lithium therapy: enhanced lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal function.
  • ACE inhibitors or ARBs: possible reduction in renal perfusion.
  • Methotrexate: increased plasma levels of methotrexate.

Frequently Asked Questions

Metafen Forte is a topical formulation containing ibuprofen lysine that is used to relieve localized musculoskeletal pain, reduce inflammation, and treat sports‑related injuries such as sprains and strains. It is applied directly to the skin over the affected area to provide targeted relief.

Ibuprofen lysine works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues. This inhibition lowers the production of prostaglandins, which are mediators of inflammation and pain, thereby decreasing swelling and discomfort at the site of application.

The appropriate amount of Metafen Forte to apply is determined by the prescribing healthcare professional based on the size of the affected area, severity of symptoms, and patient factors. Users should follow the specific instructions provided on the product label or by their clinician.

Safety of topical ibuprofen lysine during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Metafen Forte to weigh potential risks and benefits.

To order Metafen Forte, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Metafen Forte delivers ibuprofen lysine, which offers rapid skin penetration and a high local concentration compared with some other topical NSAIDs that use ibuprofen base. This can result in quicker onset of pain relief, while the safety profile remains similar to other NSAID gels and creams.

Metafen Forte should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and extreme heat. Ensure the container is tightly closed when not in use to maintain stability.

Apply a thin layer of Metafen Forte to clean, dry skin over the painful or inflamed area. Gently massage until the gel is absorbed, typically 2–3 minutes. Do not cover the area with airtight dressings unless directed by a healthcare professional, and wash hands after application.

Serious risks, though rare, include severe allergic skin reactions such as Stevens‑Johnson syndrome, systemic gastrointestinal bleeding, acute renal impairment, hepatic dysfunction, and anaphylaxis. Users should discontinue use and seek immediate medical attention if they experience widespread rash, swelling, difficulty breathing, or signs of internal bleeding.

Metafen Forte should be avoided by individuals with known hypersensitivity to ibuprofen, other NSAIDs, or any component of the formulation. It is also contraindicated on broken, infected or severely damaged skin, and should be used with caution in patients with severe renal, hepatic or cardiovascular disease unless advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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