Product image of Metafen (Ibuprofen, Paracetamol) supplied by GNH India

Metafen

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Metafen (Ibuprofen, Paracetamol)

Ibuprofen and Paracetamol, the active ingredients in Metafen, are analgesic and antipyretic agents presented as an oral combination for systemic use. They are used to relieve mild to moderate pain and reduce fever in adults and children when appropriate.

GNH India supplies Metafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable sourcing for global healthcare providers.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metafen, a combination of ibuprofen and paracetamol, acts on pain and fever pathways to provide symptomatic relief.

  • Pain relief: reduces mild to moderate pain such as dental, menstrual or postoperative discomfort.
  • Fever reduction: lowers elevated body temperature in febrile conditions.
  • Headache: alleviates tension‑type or early migraine headache.
  • Musculoskeletal pain: eases aches from strains, sprains or arthritis.
  • Post‑operative discomfort: helps manage pain after minor surgical procedures.

How It Works

  • Ibuprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and providing anti‑inflammatory and analgesic effects. Paracetamol acts centrally to inhibit COX activity and modulate pain and temperature pathways, producing analgesic and antipyretic actions. The combined effect offers complementary pain relief and fever control.

Side Effects

Metafen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea or upset stomach.
  • Headache.
  • Dizziness.
  • Mild skin rash.
  • Indigestion.
  • Diarrhoea.

Serious or Rare Side Effects

  • Gastrointestinal bleeding or ulceration.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Elevated liver enzymes or hepatic injury.
  • Acute kidney impairment.
  • Anaphylactic reaction.
  • Blood dyscrasias (e.g., thrombocytopenia).

Precautions & Warnings

Before using Metafen, consider the following safety measures.

  • Do not exceed the recommended daily dose: follow prescriber or label guidance.
  • Take with food or milk: helps reduce gastrointestinal irritation.
  • Avoid if you have a known allergy to NSAIDs or acetaminophen.
  • Use caution in patients with liver disease: monitor hepatic function.
  • Use caution in patients with kidney disease: monitor renal function.
  • Limit alcohol consumption: it may increase risk of liver injury.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metafen can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or high‑dose aspirin: heightened gastrointestinal toxicity.
  • Lithium: ibuprofen may raise lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: ibuprofen may reduce blood‑pressure‑lowering effect.
  • Diuretics: possible reduction in renal clearance.
  • SSRIs: may modestly increase bleeding tendency.
  • Methotrexate: ibuprofen can raise methotrexate concentrations.
  • Corticosteroids: combined use may increase ulcer risk.

Frequently Asked Questions

Metafen is an oral combination of ibuprofen and paracetamol used to relieve mild to moderate pain such as headache, dental or musculoskeletal discomfort, and to reduce fever in febrile conditions.

Ibuprofen blocks cyclooxygenase enzymes, lowering prostaglandin production and reducing inflammation and pain. Paracetamol works centrally to inhibit COX activity and modulate temperature regulation, providing additional analgesic and antipyretic effects.

The appropriate dose of Metafen is determined by a prescriber based on the patient’s age, weight, clinical condition and local labeling. Patients should follow the specific instructions provided by their healthcare professional.

Safety of ibuprofen and paracetamol during pregnancy or lactation depends on the trimester and individual risk factors. Healthcare providers should evaluate the benefit‑risk balance before prescribing Metafen to pregnant or nursing women.

To request Metafen, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metafen combines an NSAID (ibuprofen) with a centrally acting analgesic (paracetamol), offering broader pain and fever control than either agent alone. This dual mechanism can provide better symptom relief than single‑ingredient products, while maintaining an OTC safety profile.

Metafen should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.

Metafen is taken orally, usually with a full glass of water. It may be taken with food or milk to lessen potential stomach irritation, following the dosage instructions provided by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe skin reactions such as Stevens‑Johnson syndrome, liver injury, kidney impairment, and rare anaphylactic reactions. Patients should seek immediate medical attention if they notice any of these symptoms.

Metafen should be avoided by individuals with known hypersensitivity to ibuprofen, other NSAIDs, or paracetamol, as well as patients with active gastrointestinal ulcers, severe liver or kidney disease, and those on anticoagulant therapy without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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