Product image of Metafen Max (Paracetamol) supplied by GNH India

Metafen Max

Active Ingredient:
Paracetamol
Origin:
EU

Metafen Max (Paracetamol)

Paracetamol, the active ingredient in Metafen Max, is an analgesic, antipyretic presented as an oral tablet for oral use. It is commonly employed to relieve mild to moderate pain and to reduce fever in adults and children when appropriate dosing is applied.

GNH India supplies Metafen Max as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU manufacturing standards and providing regulatory documentation for global distribution.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Paracetamol is used to manage pain and fever by acting on the central prostaglandin pathway.

  • Headache: provides relief from tension‑type or mild migraine pain.
  • Musculoskeletal pain: reduces discomfort from strains, sprains, and arthritis.
  • Dental pain: alleviates postoperative or procedural discomfort.
  • Fever: lowers elevated body temperature associated with infections or inflammatory conditions.

How It Works

  • Paracetamol exerts its analgesic and antipyretic actions primarily through inhibition of cyclooxygenase enzymes in the central nervous system, leading to reduced synthesis of prostaglandins that mediate pain perception and thermoregulation. This central inhibition diminishes nociceptive signaling and resets the hypothalamic set‑point for body temperature.

Side Effects

Paracetamol may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: occasional feeling of stomach upset.
  • Abdominal discomfort: mild stomach pain or indigestion.
  • Rash: transient skin redness or itching.
  • Dizziness: brief sensation of light‑headedness.
  • Increased liver enzymes: mild elevation detectable in laboratory tests.
  • Sweating: occasional excessive perspiration.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Hepatotoxicity: potential liver injury, especially with overdose.
  • Blood disorders: rare cases of agranulocytosis or thrombocytopenia.
  • Anaphylaxis: life‑threatening allergic reaction with breathing difficulty.

Precautions & Warnings

Paracetamol should be used with caution in specific populations and clinical situations.

  • Dosage adjustment: reduce dose in patients with hepatic impairment.
  • Alcohol use: avoid excessive alcohol as it may increase liver risk.
  • Allergy: discontinue if hypersensitivity reactions such as rash or swelling occur.
  • Pregnancy: consult a healthcare professional before use during pregnancy.
  • Concurrent medications: review use with other hepatotoxic drugs.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Isoniazid: heightened hepatotoxic potential.
  • Phenobarbital: may reduce paracetamol effectiveness.

Moderate Interactions (Monitor Closely)

  • Alcohol: may exacerbate liver toxicity.
  • Other paracetamol‑containing products: risk of cumulative overdose.
  • Carbamazepine: may increase hepatic metabolism of paracetamol.

Frequently Asked Questions

Metafen Max contains paracetamol, which is used to relieve mild to moderate pain such as headaches, muscle aches, dental pain, and to lower fever associated with common infections. It is an over‑the‑counter option for short‑term symptom management.

Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, reducing the production of prostaglandins that signal pain and regulate body temperature. This central action provides analgesic and antipyretic effects without significant anti‑inflammatory activity.

The appropriate dose of Metafen Max is determined by a prescriber or according to the product labeling, taking into account the patient’s age, weight, and clinical condition. Users should follow the recommended dosage instructions provided with the medication.

Paracetamol is generally considered the analgesic of choice during pregnancy and lactation when used at recommended doses, but pregnant or nursing individuals should consult their healthcare professional before starting Metafen Max to confirm safety for their specific situation.

To order Metafen Max, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs), paracetamol in Metafen Max offers effective pain and fever relief with a lower risk of gastrointestinal irritation and platelet inhibition, but it lacks the anti‑inflammatory properties of NSAIDs. It is often chosen when NSAIDs are contraindicated.

Metafen Max should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Metafen Max is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless the product label specifically permits it. Follow the dosing schedule advised by a healthcare professional.

The most serious risks include severe liver injury, especially with overdose or when combined with alcohol or other hepatotoxic drugs, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Prompt medical attention is required if signs of liver dysfunction or severe allergic reactions appear.

Individuals with known hypersensitivity to paracetamol, severe liver disease, or those who are regularly consuming high amounts of alcohol should avoid Metafen Max unless directed by a physician. It is also contraindicated in patients taking other paracetamol‑containing products without proper dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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