Product image of Metafen Zatoki (Pseudoephedrine Hydrochloride, Ibuprofen) supplied by GNH India

Metafen Zatoki

Active Ingredient:
Pseudoephedrine Hydrochloride, Ibuprofen
Origin:
EU

Metafen Zatoki (Pseudoephedrine Hydrochloride, Ibuprofen)

Pseudoephedrine Hydrochloride, the active ingredient in Metafen Zatoki, is a sympathomimetic decongestant presented as an oral tablet for oral use. It relieves nasal congestion while ibuprofen, a non‑steroidal anti‑inflammatory drug, reduces pain and fever, providing combined symptom relief for upper‑respiratory conditions.

GNH India supplies Metafen Zatoki as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metafen Zatoki combines a nasal decongestant and an NSAID to address symptoms of upper‑respiratory tract infections.

  • Common cold: reduces nasal congestion, sinus pressure and fever.
  • Acute sinusitis: alleviates sinus pain and swelling while clearing nasal passages.
  • Influenza‑like illness: provides analgesic and antipyretic effects together with decongestion.

How It Works

  • Pseudoephedrine stimulates α‑adrenergic receptors in the nasal mucosa, causing vasoconstriction and reduced edema, while ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby lowering inflammation, pain, and fever.

Side Effects

Metafen Zatoki may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Dizziness: transient light‑headedness.
  • Insomnia: difficulty falling asleep.
  • Dry mouth: reduced salivation.
  • Stomach upset: mild abdominal discomfort.

Serious or Rare Side Effects

  • Hypertension: significant rise in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Gastrointestinal bleeding: blood in stool or vomiting blood.
  • Renal impairment: reduced kidney function.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before using Metafen Zatoki, consider the following safety measures.

  • Cardiovascular disease: monitor blood pressure and heart rate.
  • Pregnancy: consult a healthcare professional; use only if benefits outweigh risks.
  • Breastfeeding: discuss with a physician; ibuprofen is generally compatible, pseudoephedrine may pass into milk.
  • Existing kidney or liver disease: assess suitability with a clinician.
  • Drug allergies: avoid if known hypersensitivity to pseudoephedrine, ibuprofen, or related compounds.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metafen Zatoki can interact with several medication classes; awareness helps prevent adverse outcomes. Major Interactions (Avoid):\n- Monoamine oxidase inhibitors: risk of hypertensive crisis with pseudoephedrine.

  • Anticoagulants (e.g., warfarin): ibuprofen may increase bleeding risk.
  • Other sympathomimetics: additive cardiovascular stimulation.
  • ACE inhibitors: pseudoephedrine may reduce antihypertensive effect.
  • Selective serotonin reuptake inhibitors: potential for increased serotonergic activity.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible attenuation of blood‑pressure control.
  • Diuretics: enhanced risk of electrolyte imbalance.
  • Lithium: pseudoephedrine may raise lithium levels.
  • Other NSAIDs: additive gastrointestinal irritation.
  • Corticosteroids: increased risk of ulceration.

Frequently Asked Questions

Metafen Zatoki is a fixed‑dose oral tablet that combines pseudoephedrine, a nasal decongestant, with ibuprofen, an anti‑inflammatory analgesic. It is used to relieve nasal congestion, sinus pressure, headache, fever, and general discomfort associated with common colds, acute sinusitis, and influenza‑like illnesses.

Pseudoephedrine acts on α‑adrenergic receptors in the nasal mucosa, causing vasoconstriction of the blood vessels. This reduces swelling of the nasal passages, leading to improved airflow and relief of congestion.

The appropriate dose of Metafen Zatoki is determined by the prescribing healthcare professional based on the patient’s age, weight, medical condition, and other medications. Patients should follow the prescriber’s instructions and the product label.

Pregnancy and breastfeeding decisions should be made with a qualified healthcare provider. Ibuprofen is generally avoided in the third trimester, while pseudoephedrine may be used if the benefit outweighs potential risks. Professional guidance is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metafen Zatoki uniquely combines a decongestant and an NSAID in a single tablet, offering simultaneous relief of congestion and pain/fever. Many alternatives provide only one of these actions, requiring separate medications for full symptom control.

Store Metafen Zatoki at ambient temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency.

Metafen Zatoki is taken orally with a full glass of water. It should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include significant elevation of blood pressure, cardiac arrhythmias, severe allergic reactions such as anaphylaxis, gastrointestinal bleeding, and potential kidney or liver impairment. Patients should seek immediate medical attention if they experience any of these symptoms.

Metafen Zatoki should be avoided by individuals with known hypersensitivity to pseudoephedrine, ibuprofen, or any component of the formulation, as well as patients with uncontrolled hypertension, severe coronary artery disease, recent myocardial infarction, or active gastrointestinal ulceration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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