Product image of Metafenex (Ibuprofen, Paracetamol) supplied by GNH India

Metafenex

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Metafenex (Ibuprofen, Paracetamol)

Ibuprofen and Paracetamol, the active ingredients in Metafenex, are a non‑steroidal anti‑inflammatory drug (NSAID) and an analgesic/antipyretic respectively, presented as an oral combination for systemic use. Together they provide relief from mild to moderate pain, fever, headache and musculoskeletal discomfort in adults and, when dosed appropriately, in pediatric patients. The formulation is intended for short‑term symptom management and is available over the counter in the European market.

GNH India supplies Metafenex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metafenex, a combined ibuprofen and paracetamol preparation, acts on inflammatory and pain pathways to provide symptomatic relief.

  • Mild to moderate pain: reduces pain intensity and improves functional comfort.
  • Fever: lowers elevated body temperature.
  • Headache: alleviates tension and vascular headache symptoms.
  • Musculoskeletal pain: eases discomfort associated with strains, sprains and arthritis.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain and fever. Paracetamol acts centrally to inhibit COX enzymes and modulates the endocannabinoid system, providing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Metafenex may cause a range of adverse reactions. Most are mild and reversible, but serious events can occur.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dyspepsia: discomfort or burning in the stomach.
  • Dizziness: transient light‑headedness.
  • Rash: mild skin irritation.
  • Headache: occasional worsening of head pain.
  • Elevated liver enzymes: mild, transient increase.

Serious or Rare Side Effects

  • Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
  • Peptic ulcer perforation: severe stomach ulcer complications.
  • Severe allergic reaction (anaphylaxis): rapid onset of airway compromise.
  • Hepatotoxicity: significant liver injury, especially with overdose.
  • Acute kidney injury: reduced renal function, particularly in dehydrated patients.
  • Stevens‑Johnson syndrome: rare severe skin reaction.

Precautions & Warnings

Before using Metafenex, consider the following safety measures.

  • Assess renal function: avoid in severe renal impairment.
  • Evaluate hypersensitivity: do not use if allergic to ibuprofen or paracetamol.
  • Use cautiously in asthma or cardiovascular disease: monitor symptoms.
  • Limit alcohol consumption: reduces risk of liver injury.
  • Do not exceed recommended daily dose: prevents toxicity.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metafenex can interact with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Hepatotoxic drugs (e.g., isoniazid, methotrexate): elevated risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, beta‑blockers): possible reduction in blood pressure control.
  • Diuretics (e.g., furosemide): may affect renal function.
  • Lithium: ibuprofen can raise lithium serum levels, requiring dose adjustment.

Frequently Asked Questions

Metafenex is an over‑the‑counter oral combination of ibuprofen and paracetamol indicated for the temporary relief of mild to moderate pain such as headache, musculoskeletal discomfort, and for reducing fever.

Ibuprofen blocks cyclooxygenase‑1 and ‑2 enzymes, lowering prostaglandin production and thus reducing inflammation, pain and fever. Paracetamol acts mainly in the central nervous system to inhibit COX activity and modulate the endocannabinoid system, providing analgesic and antipyretic effects.

The appropriate dose of Metafenex is determined by a prescriber or according to the product labeling. The prescribing healthcare professional will set the dose based on the patient’s age, weight, clinical condition and any relevant medical history.

Safety in pregnancy and lactation depends on the specific clinical situation. Ibuprofen is generally avoided in the third trimester, while paracetamol is considered relatively safe when used at recommended doses. Patients should consult their healthcare provider before using Metafenex while pregnant or breastfeeding.

To order Metafenex, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metafenex combines an NSAID (ibuprofen) with a centrally acting analgesic/antipyretic (paracetamol), offering broader symptom control than either agent alone. Compared with single‑ingredient products, the combination can provide enhanced pain relief and fever reduction, but it also carries the combined safety profile of both drugs.

Metafenex should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Metafenex is taken orally with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The exact administration instructions are provided on the product label.

Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions (anaphylaxis), significant liver injury, and acute kidney impairment. Patients should seek immediate medical attention if they experience symptoms such as vomiting blood, severe abdominal pain, rash, or sudden loss of kidney function.

Metafenex should be avoided by individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients, those with active peptic ulcer disease, severe renal or hepatic impairment, and by patients in the third trimester of pregnancy unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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