Product image of Metaflu (Sodium Fluoride (18f)) supplied by GNH India

Metaflu

Active Ingredient:
Sodium Fluoride (18f)
Origin:
EU

Metaflu (Sodium Fluoride (18f))

Sodium fluoride, the active ingredient in Metaflu, is a fluoride presented as an intravenous solution for intravenous use. It helps prevent dental caries and treats fluoride deficiency in patients requiring systemic supplementation.
GNH India supplies Metaflu as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Synektik S.A.

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Indications & Clinical Uses

Metaflu is used within the fluoride therapeutic class to address conditions that benefit from systemic fluoride supplementation.

  • Dental caries prevention: provides systemic fluoride to strengthen enamel and reduce decay risk.
  • Fluoride deficiency treatment: restores normal fluoride levels in individuals with inadequate dietary intake.
  • Adjunct in osteoporosis management: supplies fluoride ions that may support bone mineralization under specialist supervision.

How It Works

  • Sodium fluoride dissociates to release fluoride ions that incorporate into hydroxyapatite crystals of dental enamel and bone, forming fluorapatite which is more resistant to acid dissolution. The ions also inhibit bacterial enolase, reducing bacterial metabolism and acid production, thereby contributing to caries prevention and supporting mineralization processes.

Side Effects

Fluoride administration can be associated with a range of adverse reactions.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort.
  • Metallic taste: transient alteration in oral sensation.
  • Local irritation: redness or pain at the injection site.
  • Headache: mild to moderate intensity.
  • Low serum calcium: mild hypocalcemia in susceptible individuals.

Serious or Rare Side Effects

  • Acute fluoride toxicity: symptoms may include vomiting, abdominal pain, and cardiac arrhythmias.
  • Severe hypocalcemia: can lead to tetany or seizures.
  • Anaphylactic reaction: rare but possible systemic allergic response.
  • Renal impairment: fluoride accumulation in patients with reduced kidney function.

Precautions & Warnings

When using Metaflu, consider the following safety measures.

  • Assess baseline fluoride status: evaluate dietary intake and existing fluoride exposure.
  • Monitor serum calcium: watch for signs of hypocalcemia during therapy.
  • Adjust dose in renal impairment: reduce dosage or increase monitoring frequency.
  • Avoid concurrent high‑dose fluoride products: prevent cumulative toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Fluoride can interact with several medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Calcium supplements: may reduce fluoride absorption and increase risk of hypocalcemia.
  • Aluminum-containing antacids: can form insoluble complexes, decreasing fluoride bioavailability.

Moderate Interactions (Monitor Closely)

  • Vitamin D analogues: may enhance calcium and phosphate shifts, necessitating electrolyte monitoring.
  • Loop diuretics: increase renal excretion of fluoride, potentially reducing efficacy.
  • Anticonvulsants (e.g., phenobarbital): may alter fluoride metabolism, requiring periodic serum level checks.

Frequently Asked Questions

Metaflu is an intravenous sodium fluoride solution used to provide systemic fluoride for the prevention of dental caries, to treat fluoride deficiency, and, under specialist guidance, as an adjunct in bone health management such as osteoporosis.

Sodium fluoride releases fluoride ions that become incorporated into tooth enamel and bone, forming fluorapatite, which is more resistant to acid attack. The ions also inhibit bacterial enzymes, reducing acid production and supporting mineralization.

The appropriate dose of Metaflu is determined by the prescribing clinician based on the patient’s age, weight, fluoride status, and clinical indication. Dosage regimens are individualized and should follow professional medical guidance.

Safety data for Metaflu in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when possible. Use only if clearly indicated and prescribed by a qualified healthcare professional.

To request Metaflu, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Metaflu delivers fluoride intravenously, offering rapid systemic availability compared with oral tablets or topical gels. This route is useful for patients unable to take oral formulations or who require controlled dosing, whereas traditional fluoride supplements are administered orally and have slower absorption.

Metaflu should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the solution. Keep the product in its original packaging to maintain stability.

Metaflu is administered by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and duration are set by the prescriber according to the patient’s clinical needs and monitoring parameters.

Serious risks include acute fluoride toxicity, which can cause vomiting, abdominal pain, cardiac arrhythmias, and severe hypocalcemia leading to tetany or seizures. Anaphylactic reactions, though rare, also represent a critical safety concern.

Metaflu should be avoided in patients with known hypersensitivity to fluoride, severe renal impairment, uncontrolled electrolyte disturbances, or those receiving high‑dose calcium or aluminum‑containing medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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