What is Metalcaptase used for?

Metalcaptase

Active Ingredient:: Penicillamine
Origin:: EU

Metalcaptase (Penicillamine)

Penicillamine, the active ingredient in Metalcaptase, is a chelating agent presented as an oral dosage form for oral use. It is employed in the management of Wilson disease, rheumatoid arthritis, and cystinuria, helping to remove excess copper and other metals and modulating immune activity.

GNH India supplies Metalcaptase as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg

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Indications & Clinical Uses

Metalcaptase is a chelating agent indicated for several metabolic and autoimmune conditions.

Wilson disease: reduces copper accumulation, improving hepatic and neurological function.
Rheumatoid arthritis: decreases disease activity by modulating immune response and collagen cross‑linking.
Cystinuria: lowers urinary cystine levels, helping to prevent stone formation.

How It Works

Penicillamine binds copper and other heavy metals through its sulfhydryl group, forming stable complexes that are excreted in the urine. It also interferes with collagen cross‑linking, reducing tissue damage, and exhibits immunomodulatory effects by altering T‑cell function, contributing to its efficacy in rheumatoid arthritis and cystinuria.

Side Effects

Adverse reactions may occur with penicillamine therapy.

Common Side Effects

Nausea and vomiting
Loss of appetite
Metallic taste in the mouth
Fatigue or mild rash

Serious or Rare Side Effects

Agranulocytosis or severe neutropenia
Stevens‑Johnson syndrome or toxic epidermal necrolysis
Significant liver toxicity or hepatitis

Precautions & Warnings

Careful monitoring is required when using Metalcaptase.

Monitor renal function: assess serum creatinine and urine output regularly.
Monitor hepatic function: check liver enzymes and bilirubin periodically.
Avoid in patients with known hypersensitivity to penicillamine.
Use caution with concomitant zinc therapy as it may reduce absorption.
Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Penicillamine may interact with several medicines.

Major Interactions (Avoid)

Zinc supplements: reduce penicillamine absorption; concurrent use should be avoided.
Pyridoxine (vitamin B6) high doses: increase risk of neuropathy; avoid combination.

Moderate Interactions (Monitor Closely)

Methotrexate: may enhance toxicity; monitor blood counts and liver function.
ACE inhibitors: potential additive renal effects; observe renal parameters.
Oral contraceptives: may decrease efficacy; consider alternative contraception.

Frequently Asked Questions

Metalcaptase contains penicillamine and is prescribed for Wilson disease to lower copper levels

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 04 Sep 2026

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