Metamizol Abz (Metamizole Sodium Monohydrate)

Metamizole is used in several clinical situations where pain or fever requires effective relief.

• Mild to moderate pain: provides analgesia for everyday injuries, musculoskeletal discomfort, and dental pain.
• Fever: reduces elevated body temperature in acute infectious or inflammatory conditions.
• Post‑operative pain: helps control pain after surgical procedures to improve patient comfort.
• Colic: alleviates visceral pain associated with gastrointestinal colic, including renal colic.
• Acute visceral pain: offers rapid analgesic effect for sudden internal organ pain such as biliary or uterine cramps.

• Metamizole inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, which reduces the formation of pain‑inducing and fever‑inducing mediators. In addition, it exerts central analgesic activity through modulation of spinal and supraspinal pathways, contributing to its antipyretic and analgesic effects without significant anti‑inflammatory activity.

Metamizole may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Vomiting: occasional episodes after dosing.
• Dizziness: transient light‑headedness.
• Headache: mild to moderate intensity.
• Skin rash: mild erythematous reactions.
• Mild hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

• Agranulocytosis: severe reduction in white blood cells, potentially life‑threatening.
• Severe allergic reactions: including anaphylaxis and angioedema.
• Hepatic enzyme elevation: possible liver function abnormalities.
• Severe hypotension: marked blood pressure drop requiring medical attention.
• Blood dyscrasias: rare hematologic disorders.
• Anaphylactic shock: immediate hypersensitivity requiring emergency care.

When prescribing Metamizole, clinicians should consider several safety measures.

• Assess renal function: adjust use in patients with impaired kidney function.
• Monitor blood counts: regular hematologic monitoring to detect agranulocytosis.
• Avoid in known hypersensitivity: contraindicated for patients with previous allergic reactions to pyrazolones.
• Use with caution in the elderly: increased susceptibility to adverse effects.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Metamizole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

• Other pyrazolone analgesics: combined use heightens risk of agranulocytosis.
• Anticoagulants: may increase bleeding tendency.
• Methotrexate: can enhance methotrexate toxicity.

Moderate Interactions (Monitor Closely)

• NSAIDs: additive gastrointestinal irritation and renal effects.
• CYP450 inhibitors: may raise Metamizole plasma levels.
• Diuretics: can potentiate hypotensive effects.