Product image of Metamizol Aristo (Metamizole Magnesium) supplied by GNH India

Metamizol Aristo

Active Ingredient:
Metamizole Magnesium
Origin:
EU

Metamizol Aristo (Metamizole Magnesium)

Metamizole magnesium, the active ingredient in Metamizol Aristo, is a pyrazolone presented as an oral formulation for systemic use. It is used to relieve pain, reduce fever, and alleviate visceral colic in adult patients under medical supervision.

GNH India supplies Metamizol Aristo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aristo Pharma Iberia, S.L.

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Indications & Clinical Uses

Metamizol Aristo is employed in the management of conditions that involve acute pain, fever, or smooth‑muscle spasm.

  • Pain: provides analgesic relief for moderate to severe acute pain.
  • Fever: reduces elevated body temperature in febrile states.
  • Visceral colic: eases spasm‑related discomfort in gastrointestinal or biliary colic.

How It Works

  • Metamizole magnesium exerts its effect by inhibiting cyclooxygenase enzymes, which reduces prostaglandin synthesis, and by modulating central pain pathways. The combined peripheral and central actions contribute to its analgesic, antipyretic, and spasmolytic properties, although the exact molecular mechanisms remain partially elucidated.

Side Effects

Metamizol Aristo may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Rash: skin erythema or mild itching.
  • Hypotension: occasional drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells, requiring immediate medical attention.
  • Anaphylaxis: life‑threatening allergic reaction with airway compromise.
  • Hepatotoxicity: rare liver enzyme elevations or injury.

Precautions & Warnings

When prescribing Metamizol Aristo, clinicians should consider several safety measures.

  • Renal impairment: assess kidney function before use.
  • Hepatic disease: monitor liver enzymes during therapy.
  • Hematologic disorders: avoid in patients with a history of agranulocytosis.
  • Concomitant anticoagulants: watch for increased bleeding risk.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizol Aristo can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding tendency.
  • Immunosuppressants (e.g., azathioprine): heightened risk of bone‑marrow suppression.

Moderate Interactions (Monitor Closely)

  • Other NSAIDs or pyrazolones: additive gastrointestinal irritation.
  • Diuretics: possible enhancement of hypotensive effect.
  • Lithium: may increase lithium serum levels.

Frequently Asked Questions

Metamizol Aristo is prescribed to manage moderate to severe acute pain, to lower elevated body temperature in febrile patients, and to relieve smooth‑muscle spasm associated with visceral colic such as biliary or gastrointestinal cramps.

Metamizole magnesium inhibits cyclooxygenase enzymes, decreasing prostaglandin production, and also modulates central pain pathways. This dual action provides analgesic, antipyretic, and spasmolytic effects, although the precise molecular details are not fully defined.

The dosage of Metamizol Aristo is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Only a qualified health professional should set the appropriate regimen.

Safety data for Metamizole magnesium in pregnancy and lactation are limited. It should be used only when the potential therapeutic benefit justifies the possible risk to the fetus or infant, and only under medical supervision.

To request Metamizol Aristo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional NSAIDs, Metamizole magnesium offers analgesic and antipyretic effects with a lower incidence of gastrointestinal ulceration, but it carries a rare risk of agranulocytosis. Clinicians weigh these differences when selecting therapy for individual patients.

Metamizol Aristo should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and sources of heat to maintain stability.

Metamizol Aristo is taken orally, usually as a tablet or oral solution, and should be swallowed with water. The exact administration instructions, including timing relative to meals, are provided by the prescribing physician.

The most serious adverse reactions include agranulocytosis, a potentially life‑threatening drop in white‑blood‑cell count, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical care if they develop signs of infection, fever, or allergic symptoms.

Metamizol Aristo is contraindicated in individuals with a known hypersensitivity to metamizole or other pyrazolones, in patients with a history of agranulocytosis, and in those with severe hepatic or renal impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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