Product image of Metamizol Aristo (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Aristo

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Aristo (Metamizole Sodium Monohydrate)

Metamizole sodium monohydrate, the active ingredient in Metamizol Aristo, is a pyrazolone presented as an oral formulation for oral use. It treats pain and fever in adult patients.
GNH India supplies Metamizol Aristo as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

  • Metamizole sodium is an analgesic/antipyretic used to manage pain and fever.
  • Pain: provides relief of moderate to severe pain.
  • Fever: reduces elevated body temperature.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Cancer‑related pain: may be employed for severe pain associated with malignancy.
  • Acute musculoskeletal pain: alleviates pain from injuries or strain.

How It Works

  • Metamizole sodium inhibits cyclo‑oxygenase enzymes, leading to decreased prostaglandin synthesis. It also modulates inflammatory pathways by affecting cytokine release and neuronal excitability, resulting in reduced pain perception and antipyretic effects without strong peripheral anti‑inflammatory activity.

Side Effects

Metamizole sodium may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness
  • Headache
  • Skin rash
  • Mild hypotension

Serious or Rare Side Effects

  • Agranulocytosis (dangerously low white blood cell count)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Anaphylactic shock
  • Hepatic failure
  • Renal impairment
  • Blood dyscrasias including thrombocytopenia

Precautions & Warnings

  • Use of Metamizole sodium requires careful clinical consideration.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Monitor blood counts: regular hematologic monitoring is advised.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Use caution in cardiovascular disease: monitor blood pressure due to possible hypotension.
  • Consider hepatic impairment: dose adjustment may be necessary.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metamizole sodium can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants: increased risk of bleeding.
  • Other NSAIDs: heightened gastrointestinal ulcer risk.
  • Methotrexate: enhanced toxicity and reduced clearance.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible reduction in blood‑pressure control.
  • Lithium: may raise lithium serum levels, requiring monitoring.

Frequently Asked Questions

Metamizol Aristo contains metamizole sodium monohydrate, which is employed as an analgesic and antipyretic to relieve moderate to severe pain and to reduce fever in adult patients. It is commonly used in postoperative settings, cancer‑related pain, and acute musculoskeletal discomfort.

Metamizole sodium works by inhibiting cyclo‑oxygenase enzymes, which lowers prostaglandin production. It also influences inflammatory pathways and neuronal signaling, leading to decreased pain perception and a reduction in body temperature without strong peripheral anti‑inflammatory effects.

The appropriate dose of Metamizol Aristo is determined by the prescribing healthcare professional based on the individual’s condition, severity of symptoms, age, and renal or hepatic function. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety data for metamizole sodium in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Healthcare providers should weigh potential benefits against risks before prescribing it to pregnant or nursing women.

To order Metamizol Aristo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metamizole sodium belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct safety profile. Compared with traditional NSAIDs, it may have a lower risk of gastrointestinal irritation but carries a rare risk of agranulocytosis, requiring blood‑count monitoring.

Metamizol Aristo should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture. Keep the product away from direct sunlight and out of reach of children.

Metamizol Aristo is formulated for oral administration. The tablets or oral solution should be taken with water as directed by the prescriber, usually with or without food, depending on individual tolerance and the specific clinical situation.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if signs of infection, unexplained fever, or skin changes occur.

Metamizol Aristo should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, in patients with a history of agranulocytosis, and in those with severe liver or kidney impairment unless closely monitored by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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