Product image of Metamizol Auxilto (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Auxilto

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Auxilto (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Auxilto, is a pyrazolone derivative presented as an oral formulation for systemic use. It is employed to manage moderate to severe pain and to reduce fever in adult patients. The drug is classified as an analgesic and antipyretic and is available by prescription in the European market.

GNH India supplies Metamizol Auxilto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Auxilto Healthcare S.R.O.

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Indications & Clinical Uses

  • Metamizole sodium is used for pain and fever management by inhibiting prostaglandin synthesis.
  • Moderate to severe pain: provides analgesic relief when other agents are insufficient.
  • Postoperative pain: helps control pain after surgical procedures.
  • Fever: reduces elevated body temperature in acute febrile states.

How It Works

  • Metamizole sodium inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis, and also modulates central pain pathways in the spinal cord and brain, thereby producing analgesic and antipyretic effects.

Side Effects

Metamizole sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Vomiting: occasional episodes.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythema.

Serious or Rare Side Effects

  • Agranulocytosis: severe drop in white blood cells, potentially life‑threatening.
  • Anaphylactic reaction: rapid onset of hypersensitivity.
  • Severe hypotension: sudden drop in blood pressure.
  • Hepatotoxicity: liver enzyme elevation.

Precautions & Warnings

  • Precautions should be observed when prescribing Metamizole sodium.
  • Renal impairment: monitor kidney function.
  • Hepatic disease: use with caution.
  • History of blood dyscrasias: avoid if prior agranulocytosis.
  • Concomitant anticoagulants: increased bleeding risk.
  • Pregnancy and lactation: safety not established, weigh risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Metamizole sodium can interact with several medicines, requiring careful assessment.

Major Interactions (Avoid)

  • Cyclooxygenase inhibitors (e.g., NSAIDs): increased risk of renal toxicity.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Immunosuppressants (e.g., methotrexate): potential bone marrow suppression.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect.
  • Lithium: possible increase in serum lithium levels.
  • Corticosteroids: additive gastrointestinal irritation.

Frequently Asked Questions

Metamizol Auxilto contains metamizole sodium, which is prescribed to relieve moderate to severe pain and to lower elevated body temperature in febrile conditions. It is commonly used in postoperative settings and for acute pain episodes where other analgesics may be insufficient.

Metamizole sodium works by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins that mediate pain and fever. In addition, it influences central pain pathways in the spinal cord and brain, contributing to its analgesic and antipyretic actions.

The dosage of Metamizol Auxilto is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Physicians tailor the regimen to achieve effective pain relief or fever control while monitoring safety.

Safety data for metamizole sodium in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole belongs to the pyrazolone class and offers strong analgesic and antipyretic effects, often comparable to high‑dose NSAIDs but without typical NSAID‑related gastric irritation. Unlike opioids, it does not produce significant respiratory depression, yet it carries a unique risk of blood‑cell disorders that must be monitored.

Metamizol Auxilto should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Metamizol Auxilto is administered orally. The tablet or oral solution is taken by mouth with or without food, as directed by the prescribing physician. Proper swallowing technique and adherence to the prescribed schedule are essential for optimal effect.

The most serious adverse events linked to metamizole sodium include agranulocytosis, a potentially fatal reduction in white blood cells, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection, sudden fever, or hypersensitivity, and treatment should be stopped immediately if these occur.

Metamizol Auxilto is contraindicated in individuals with a known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis, and those with severe hepatic or renal impairment where the risk outweighs benefit. It should also be avoided in pregnant or breastfeeding women unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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