Product image of Metamizol Auxpharma (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Auxpharma

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Auxpharma (Metamizole Sodium Monohydrate)

Metamizole, the active ingredient in Metamizol Auxpharma, is a pyrazolone analgesic presented as an oral formulation for oral use. It is employed to relieve acute pain, reduce fever, and manage post‑operative discomfort and colic in adult patients.

GNH India supplies Metamizol Auxpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Auxpharma S.R.O.

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Indications & Clinical Uses

  • Metamizole is a non‑opioid analgesic and antipyretic that acts on pain‑related and febrile pathways.
  • Acute pain: provides rapid relief of severe short‑term pain such as injury or trauma.
  • Fever: lowers elevated body temperature in infectious or inflammatory conditions.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Colic: eases visceral pain associated with gastrointestinal spasm.

How It Works

  • Metamizole exerts its effect through non‑selective inhibition of cyclooxygenase enzymes, which reduces prostaglandin synthesis. The resulting decrease in peripheral sensitisation, together with central analgesic and spasmolytic actions, contributes to pain relief and antipyretic activity.

Side Effects

Metamizole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: occasional upset stomach.
  • Vomiting: occasional emesis.
  • Dizziness: transient light‑headedness.
  • Headache: mild to moderate.
  • Skin rash: mild erythema or itching.
  • Hypotension: transient low blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Blood dyscrasias: thrombocytopenia or hemolytic anemia.
  • Hepatic enzyme elevation: possible liver injury.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Anaphylactic shock: life‑threatening hypersensitivity.

Precautions & Warnings

  • Before prescribing Metamizole, clinicians should consider several safety measures.
  • Assess renal function: adjust use in patients with impaired kidneys.
  • Monitor blood counts: periodic CBC to detect agranulocytosis.
  • Avoid in known hypersensitivity: contraindicated for patients allergic to pyrazolones.
  • Use caution in the elderly: increased risk of hypotension and renal effects.
  • Avoid concomitant use with other NSAIDs: higher risk of gastrointestinal bleeding.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metamizole can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Myelosuppressive agents: combined use may exacerbate bone‑marrow suppression.
  • Sulfonamides: increased risk of severe blood dyscrasias.
  • Anticoagulants: may enhance bleeding tendency.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation.
  • Diuretics: potential for reduced renal perfusion.
  • ACE inhibitors: possible additive hypotensive effect.

Frequently Asked Questions

Metamizol Auxpharma is indicated for the short‑term management of acute pain, fever, post‑operative pain and colic. It is prescribed when rapid analgesia or antipyresis is required, particularly in adult patients who need a non‑opioid option.

Metamizole inhibits cyclooxygenase enzymes in a non‑selective manner, decreasing prostaglandin production. Lower prostaglandin levels reduce peripheral sensitisation and central pain signalling, while also resetting the hypothalamic set‑point for temperature, thereby producing analgesic and antipyretic effects.

The specific dose of Metamizol Auxpharma is determined by the prescribing clinician based on the patient’s condition, age, weight and renal function. Healthcare professionals should follow local prescribing guidelines and adjust the regimen as needed.

Safety data for Metamizole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Metamizol Auxpharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole offers analgesic and antipyretic effects similar to NSAIDs but with a distinct pyrazolone structure. Unlike many NSAIDs, it has a lower risk of gastrointestinal ulceration but carries a rare risk of agranulocytosis. Compared with opioids, it provides pain relief without the risk of dependence or respiratory depression.

Metamizol Auxpharma should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Metamizol Auxpharma is supplied for oral use. The tablet or oral formulation is taken by mouth with water, according to the dosage prescribed by the treating physician. Swallow the medication whole; do not crush or chew unless directed.

The most serious adverse reactions include agranulocytosis, severe allergic responses such as anaphylaxis, and other blood dyscrasias. Patients should be monitored for signs of infection, rash, or unexplained bleeding, and the drug should be discontinued immediately if these occur.

Metamizol Auxpharma is contraindicated in individuals with known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis, and patients receiving concurrent myelosuppressive therapy. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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