Product image of Metamizol Cinfa (Metamizole) supplied by GNH India

Metamizol Cinfa

Active Ingredient:
Metamizole
Origin:
EU

Metamizol Cinfa (Metamizole)

Metamizole, the active ingredient in Metamizol Cinfa, is a pyrazolone analgesic presented as an oral formulation for oral use. It treats pain and fever in adult patients. GNH India supplies Metamizol Cinfa as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Metamizole is used to manage pain and fever, acting within the analgesic and antipyretic therapeutic area.

  • Pain: Reduces moderate to severe pain in adults.
  • Fever: Lowers elevated body temperature associated with various conditions.

How It Works

  • Metamizole’s exact mechanism is not fully defined, but it is thought to inhibit prostaglandin synthesis and affect central pain pathways, leading to reduced perception of pain and lowered fever. The drug may also modulate the activity of the hypothalamic thermoregulatory center.

Side Effects

Metamizole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes after dosing.
  • Dizziness: transient light‑headedness.
  • Headache: mild frontal discomfort.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Anaphylaxis: acute allergic response requiring immediate medical attention.

Precautions & Warnings

When considering Metamizole, several safety measures should be observed.

  • Medical supervision: use only under a healthcare professional’s direction.
  • Monitor blood counts: regular hematologic testing is recommended.
  • Avoid hypersensitivity: discontinue if allergic reactions occur.
  • Renal/hepatic caution: adjust use in patients with impaired kidney or liver function.
  • Pregnancy caution: avoid unless clearly needed and prescribed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Myelotoxic agents: concurrent use may increase risk of severe blood disorders.
  • Other pyrazolone derivatives: combined use can heighten toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: may enhance bleeding tendency.
  • Diuretics: possible alteration of electrolyte balance.
  • Antihypertensives: may affect blood pressure control.

Frequently Asked Questions

Metamizol Cinfa contains the analgesic Metamizole and is employed to relieve moderate to severe pain and to reduce fever in adult patients. It is commonly prescribed for postoperative pain, musculoskeletal discomfort, and febrile conditions.

The exact mechanism of Metamizole is not fully understood, but it is believed to inhibit prostaglandin synthesis and act on central pain pathways, thereby decreasing pain perception and lowering body temperature.

Dosage is individualized and must be determined by a qualified prescriber based on the patient’s condition, age, weight, and response to therapy. The prescribing information provides guidance for appropriate dosing ranges.

Safety data for Metamizole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole belongs to the pyrazolone class, offering strong analgesic and antipyretic effects similar to non‑steroidal anti‑inflammatory drugs but with a distinct safety profile, notably a risk of agranulocytosis that is not typical of many other analgesics.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture and direct sunlight to maintain stability and potency.

Metamizole is administered orally, usually in tablet or liquid form, as directed by the prescribing clinician. The route of administration is intended for systemic absorption through the gastrointestinal tract.

The most serious adverse reactions include agranulocytosis, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylactic shock. Prompt medical attention is required if signs of these conditions appear.

Metamizole should be avoided in individuals with known hypersensitivity to pyrazolones, a history of blood dyscrasias, severe renal or hepatic impairment, and in patients where safer alternatives are available, unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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