Product image of Metamizol Gemax Pharma (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Gemax Pharma

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Gemax Pharma (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Gemax Pharma, is a pyrazolone presented as an oral formulation for oral use. It is used to relieve pain, reduce fever, and treat colic in adult patients.
GNH India supplies Metamizol Gemax Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gemax Pharma S.R.O.

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Indications & Clinical Uses

Metamizol Gemax Pharma is indicated for conditions involving acute or severe pain, fever, and gastrointestinal colic.

  • Pain: provides analgesic relief for moderate to severe acute pain.
  • Fever: reduces elevated body temperature in febrile states.
  • Colic: alleviates painful intestinal or biliary colic episodes.

How It Works

  • Metamizole sodium inhibits cyclooxygenase activity, leading to reduced synthesis of prostaglandins that mediate pain and fever. While the exact pathway is not fully defined, the drug’s pyrazolone core contributes to its analgesic and antipyretic effects by modulating inflammatory mediators and central pain pathways.

Side Effects

Metamizol Gemax Pharma may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Hypotension: occasional drop in blood pressure.
  • Rash: skin redness or itching.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Anaphylactic reaction: life‑threatening allergy.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: liver injury indicated by elevated enzymes.

Precautions & Warnings

Before prescribing Metamizol Gemax Pharma, clinicians should consider several safety measures.

  • Renal function: assess kidney status in patients with impairment.
  • Hematologic monitoring: perform baseline and periodic blood counts.
  • Allergy history: avoid in individuals with known hypersensitivity to pyrazolones.
  • Concomitant myelosuppressants: use caution when combined with other bone‑marrow‑suppressing agents.
  • Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizol Gemax Pharma can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other pyrazolones: increased risk of severe blood dyscrasias.
  • Anticoagulants: potential enhancement of bleeding tendency.
  • Immunosuppressants: additive bone‑marrow suppression.

Moderate Interactions (Monitor Closely)

  • NSAIDs: heightened gastrointestinal irritation.
  • CYP450 substrates: possible alteration of metabolic clearance.
  • Alcohol: may intensify hypotensive effects.

Frequently Asked Questions

Metamizol Gemax Pharma is prescribed to manage moderate to severe acute pain, to lower elevated body temperature in febrile patients, and to relieve painful intestinal or biliary colic. It belongs to the pyrazolone class and is used when rapid analgesic or antipyretic action is required.

Metamizole sodium works by inhibiting cyclooxygenase enzymes, which reduces the production of prostaglandins—key mediators of pain, fever, and inflammation. Although the full mechanism is not completely understood, this inhibition leads to decreased sensitization of pain pathways and a lower hypothalamic set‑point for temperature regulation.

The specific dose of Metamizol Gemax Pharma is determined by the prescribing clinician based on the patient’s age, weight, severity of symptoms, and clinical condition. Healthcare professionals adjust the regimen to achieve optimal pain relief or fever reduction while monitoring safety.

Safety data for Metamizol Gemax Pharma in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metamizol Gemax Pharma belongs to the pyrazolone class, offering rapid analgesic and antipyretic effects similar to NSAIDs but with a distinct safety profile. Unlike some NSAIDs, it has a lower risk of gastrointestinal ulceration but carries a rare risk of agranulocytosis, which requires blood‑count monitoring.

Metamizol Gemax Pharma should be stored at room temperature, below 25 °C, in its original container. Protect the product from moisture, excessive heat, and direct sunlight to maintain its stability and potency throughout its shelf life.

Metamizol Gemax Pharma is administered orally. The tablet or liquid is taken with water, and the exact administration schedule is set by the prescribing clinician based on the therapeutic need and patient response.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection, skin rash, or breathing difficulties, and immediate medical attention is required if these occur.

Metamizol Gemax Pharma is contraindicated in individuals with a known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis, and those currently receiving other myelosuppressive therapies. It should also be used with caution in patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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