Product image of Metamizol Heumann (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Heumann

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Heumann (Metamizole Sodium Monohydrate)

Metamizole, the active ingredient in Metamizol Heumann, is a non‑opioid analgesic presented as an oral formulation for systemic use. It is employed to relieve moderate to severe pain and to reduce fever in adult patients across various clinical settings. It is indicated for postoperative pain, cancer‑related pain, and colic, and is available by prescription only.

GNH India supplies Metamizol Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and regulatory requirements for global distribution.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

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Indications & Clinical Uses

Metamizole is used to manage pain and fever by acting on the cyclo‑oxygenase pathway.

  • Pain: provides analgesic relief for moderate to severe acute or chronic pain.
  • Fever: reduces elevated body temperature in febrile conditions.
  • Post‑operative pain: alleviates discomfort following surgical procedures.
  • Cancer‑related pain: helps control pain associated with malignant disease.
  • Colic: eases visceral pain such as intestinal or biliary colic.

How It Works

  • Metamizole exerts its effect through non‑selective inhibition of cyclo‑oxygenase enzymes, decreasing prostaglandin synthesis, and by activating descending inhibitory pain pathways in the central nervous system, which together produce analgesic and antipyretic actions.

Side Effects

Metamizole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: transient sensation of light‑headedness.
  • Headache: occasional throbbing pain.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Agranulocytosis: severe drop in white blood cells, risk of infection.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before prescribing Metamizole, clinicians should consider several safety factors.

  • Renal impairment: monitor kidney function and adjust use as needed.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • History of blood disorders: avoid or closely monitor complete blood counts.
  • Concomitant NSAIDs: increased risk of gastrointestinal bleeding.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metamizole can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Cytotoxic chemotherapy agents: may amplify bone‑marrow suppression.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or COX inhibitors: additive gastrointestinal and renal toxicity.
  • Sulfonamide antibiotics: potential cross‑reactivity leading to hypersensitivity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive effects.
  • Diuretics: monitor blood pressure and electrolyte balance.
  • Lithium: possible increase in serum lithium levels.

Frequently Asked Questions

Metamizol Heumann contains the active ingredient Metamizole, which is prescribed to treat moderate to severe pain and to lower fever. It is commonly used after surgery, for cancer‑related pain, and for visceral pain such as colic.

Metamizole works by non‑selectively inhibiting cyclo‑oxygenase enzymes, reducing prostaglandin production, and by stimulating descending inhibitory pathways in the central nervous system. These actions together provide analgesic and antipyretic effects.

The appropriate dose of Metamizol Heumann is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Dosing instructions are provided on the prescription label and should be followed exactly.

Safety of Metamizole in pregnancy and lactation has not been firmly established. It is generally avoided unless the potential benefit justifies the possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Metamizol Heumann, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole is a non‑opioid analgesic that offers strong pain relief and antipyretic activity, often considered when NSAIDs or paracetamol are insufficient. Unlike many NSAIDs, it has a lower risk of gastrointestinal ulceration but carries a rare risk of agranulocytosis, which requires blood‑count monitoring.

Metamizol Heumann should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Metamizol Heumann is administered orally. The tablets (or oral formulation) should be swallowed whole with a full glass of water, unless otherwise directed by the prescriber. It is taken with or without food, according to individual tolerance.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, rash, or breathing difficulties, and seek immediate medical attention if they occur.

Metamizol Heumann should be avoided in individuals with known hypersensitivity to Metamizole or other sulfonamide drugs, those with a history of blood dyscrasias, severe liver or kidney disease, and in pregnant or breastfeeding women unless the prescriber determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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