Product image of Metamizol Hexal (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Hexal

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Hexal (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Hexal, is a pyrazolone presented as an oral dosage form for oral use. It belongs to the analgesic and antipyretic therapeutic class and is indicated for the treatment of acute pain, fever, and post‑operative pain in adult patients.

GNH India supplies Metamizol Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality through stringent manufacturing standards and provides regulatory documentation to support import and distribution across EU and other markets.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Metamizol Hexal, a pyrazolone analgesic and antipyretic, is used in conditions where pain or fever requires rapid relief.

  • Acute pain: provides effective analgesia for short‑term severe pain.
  • Fever: reduces elevated body temperature in febrile states.
  • Post‑operative pain: helps control discomfort following surgical procedures.

How It Works

  • Metamizole sodium inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis, which lowers inflammation and pain signaling. It also exerts central analgesic effects by modulating spinal pain pathways and possesses spasmolytic activity that contributes to its antipyretic and analgesic properties.

Side Effects

Metamizol Hexal may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional emesis.
  • Dizziness: transient light‑headedness.
  • Headache: mild cranial discomfort.
  • Rash: skin redness or mild itching.
  • Hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Blood dyscrasias: abnormal blood cell counts.
  • Severe hypotension: marked blood pressure decline.
  • Hepatic failure: rare liver injury.

Precautions & Warnings

Before prescribing Metamizol Hexal, clinicians should consider several safety measures.

  • Assess blood counts before initiating therapy: monitor for agranulocytosis.
  • Avoid use in patients with known hypersensitivity: risk of severe allergic reaction.
  • Use with caution in renal or hepatic impairment: adjust monitoring.
  • Do not combine with other NSAIDs or anticoagulants without supervision: increased bleeding risk.
  • Pregnancy and breastfeeding: consult physician, limited safety data.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Metamizol Hexal can interact with other medicines, requiring attention to potential risks.

Major Interactions (Avoid)

  • Concurrent use with other myelosuppressive agents: risk of severe bone‑marrow suppression.
  • Combination with sulfonamides: increased risk of agranulocytosis.
  • Co‑administration with anticoagulants: enhanced bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Interaction with ACE inhibitors: may potentiate hypotensive effect.
  • Use with diuretics: monitor electrolyte balance.
  • Concurrent use with other analgesics: assess cumulative toxicity.

Frequently Asked Questions

Metamizol Hexal is prescribed to relieve acute pain, reduce fever, and manage post‑operative discomfort in adult patients. It belongs to the pyrazolone class of analgesic and antipyretic medicines.

Metamizole sodium blocks cyclooxygenase enzymes, lowering prostaglandin production, which reduces inflammation and pain signals. It also acts centrally on spinal pathways and has spasmolytic activity that contributes to its antipyretic effect.

The appropriate dose of Metamizol Hexal is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Metamizol Hexal during pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit profile and consider alternative therapies when treating pregnant or nursing women.

To request Metamizol Hexal, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizol Hexal offers analgesic and antipyretic effects similar to NSAIDs but with a distinct mechanism that includes central analgesia and spasmolysis. Unlike paracetamol, it may provide stronger pain relief for certain severe conditions, though it carries a higher risk of blood‑related adverse events such as agranulocytosis.

Metamizol Hexal should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Metamizol Hexal is taken orally, usually with a glass of water. It can be administered with or without food, but patients should follow the prescriber’s guidance on timing relative to meals.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white‑blood‑cell count, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt medical attention is required if signs of infection, rash, or breathing difficulty develop.

Metamizol Hexal should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with existing blood‑cell disorders, and those who have experienced severe reactions to similar medications. Caution is also advised for patients with significant liver or kidney impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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