Product image of Metamizol Kalceks (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Kalceks

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Kalceks (Metamizole Sodium Monohydrate)

Metamizole sodium monohydrate, the active ingredient in Metamizol Kalceks, is a pyrazolone presented as an injectable solution for intramuscular and intravenous use. It treats moderate to severe pain and fever in adult patients.

GNH India supplies Metamizol Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Metamizole sodium is an analgesic/antipyretic that reduces pain and fever by inhibiting prostaglandin synthesis.

  • Pain (moderate to severe): provides rapid analgesia for acute, postoperative or traumatic pain.
  • Fever: lowers elevated body temperature in febrile conditions.
  • Post‑surgical discomfort: helps control pain after surgical procedures.

How It Works

  • Metamizole sodium monohydrate inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis in peripheral tissues and the central nervous system. This reduction dampens nociceptive signaling and lowers the hypothalamic set‑point for temperature, producing analgesic and antipyretic effects while also modulating central pain pathways.

Side Effects

Metamizole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Injection site pain: discomfort at the site of intramuscular or intravenous administration.
  • Hypotension: transient lowering of blood pressure, especially with rapid IV infusion.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: sensation of light‑headedness or vertigo.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction of white blood cells, requiring immediate medical attention.
  • Anaphylactic reaction: sudden, life‑threatening allergic response.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hemolytic anemia: destruction of red blood cells leading to anemia.

Precautions & Warnings

Metamizol should be used with careful clinical assessment and monitoring.

  • Renal function: assess kidney status and adjust use in patients with renal impairment.
  • Hepatic function: exercise caution in liver disease due to altered metabolism.
  • Hematologic monitoring: obtain baseline blood counts and monitor for agranulocytosis.
  • Allergy history: avoid in individuals with known hypersensitivity to pyrazolones.
  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Metamizol can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Concurrent myelosuppressive agents: increased risk of agranulocytosis.
  • Other NSAIDs: additive gastrointestinal and renal toxicity.
  • ACE inhibitors: may potentiate hypotensive effects.
  • Anticoagulants: heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: enzyme induction may reduce metamizole efficacy.
  • Lithium: possible elevation of lithium serum levels.
  • Warfarin: monitor INR for anticoagulant effect changes.

Frequently Asked Questions

Metamizol Kalceks is an injectable formulation of metamizole sodium monohydrate used to provide rapid relief of moderate to severe pain and to reduce high fever when other treatments are insufficient or contraindicated.

Metamizole sodium blocks cyclooxygenase enzymes, lowering prostaglandin production in peripheral tissues and the central nervous system. This action diminishes pain signaling and resets the hypothalamic temperature set‑point, resulting in analgesic and antipyretic effects.

The dose of Metamizol Kalceks is determined by the prescribing clinician based on the patient’s condition, weight, severity of pain or fever, and renal or hepatic function. No fixed regimen is provided here.

Safety data for metamizole sodium during pregnancy and lactation are limited. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified health professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Metamizole belongs to the pyrazolone class and offers strong analgesic and antipyretic effects, often considered more potent than standard NSAIDs such as ibuprofen. Unlike paracetamol, it also has antispasmodic properties, but it carries a higher risk of rare blood‑related adverse events, requiring careful monitoring.

Metamizol Kalceks should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or particulate.

The product is supplied as an injectable solution for intramuscular or intravenous administration. The route, rate of infusion, and volume are determined by the prescribing clinician, who may dilute the solution according to standard aseptic techniques.

The most serious risks include agranulocytosis, a potentially fatal drop in white‑blood‑cell count, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical evaluation is required if signs of infection, rash, or breathing difficulty occur.

Patients with known hypersensitivity to metamizole or other pyrazolones, those with existing severe blood‑cell disorders, and individuals with uncontrolled renal or hepatic impairment should avoid this medication. It is also contraindicated in pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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