Product image of Metamizol Mabo (Metamizole Magnesium) supplied by GNH India

Metamizol Mabo

Active Ingredient:
Metamizole Magnesium
Origin:
EU

Metamizol Mabo (Metamizole Magnesium)

Metamizole magnesium, the active ingredient in Metamizol Mabo, is a pyrazolone presented as an oral formulation for systemic use. It belongs to the analgesic and antipyretic therapeutic class and is employed to relieve moderate to severe pain and to reduce fever in adult patients.

GNH India supplies Metamizol Mabo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing regulatory support for cross‑border procurement. The company’s distribution network covers Europe, Asia, Africa and the Americas, ensuring reliable supply chains.

Manufacturer / TM Owner

Mabo-Farma, S.A

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Indications & Clinical Uses

Metamizole magnesium is used as an analgesic and antipyretic to manage pain and fever.

  • Acute pain: provides rapid relief of moderate to severe pain when other analgesics are insufficient.
  • Fever: reduces high temperature in cases where standard antipyretics are ineffective.
  • Post‑operative pain: helps control pain after surgical procedures.

How It Works

  • Metamizole magnesium inhibits cyclooxygenase enzymes, leading to decreased synthesis of prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels, it modulates peripheral nociceptor activity and central pain pathways, resulting in analgesic and antipyretic effects without significant anti‑inflammatory activity.

Side Effects

Metamizole magnesium may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild stomach upset.
  • Vomiting: occasional episodes.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythema.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Anaphylactic reaction: life‑threatening allergy.
  • Hepatic dysfunction: elevated liver enzymes.
  • Renal impairment: decreased kidney function.

Precautions & Warnings

When prescribing Metamizole Mabo, consider the following precautions.

  • Assess patient history: check for previous hypersensitivity to pyrazolones.
  • Monitor blood counts: perform regular CBC to detect agranulocytosis early.
  • Avoid in severe liver disease: select alternative analgesics.
  • Use caution in renal impairment: adjust therapy as clinically indicated.
  • Pregnancy and breastfeeding: use only if potential benefits outweigh risks.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metamizole magnesium can interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Concurrent use with other myelosuppressive agents: increased risk of agranulocytosis.
  • Combination with ACE inhibitors: may enhance hypotensive effect.
  • Co‑administration with other NSAIDs: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • Interaction with anticoagulants: may increase bleeding risk.
  • Use with diuretics: may affect electrolyte balance.

Frequently Asked Questions

Metamizol Mabo contains metamizole magnesium, which is prescribed as an analgesic and antipyretic. It is used to relieve moderate to severe pain and to lower high fever when other treatments are insufficient, providing rapid symptom control in adult patients.

Metamizole magnesium works by inhibiting cyclooxygenase enzymes, which reduces the production of prostaglandins—key mediators of pain, fever, and inflammation. Lower prostaglandin levels diminish peripheral nociceptor activation and central fever signaling, resulting in analgesic and antipyretic effects.

The dosage of Metamizol Mabo is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Healthcare professionals set the appropriate strength, frequency, and duration according to clinical guidelines and individual needs.

Safety data for metamizole magnesium during pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Metamizol Mabo, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metamizole magnesium offers strong analgesic and antipyretic activity, often considered when standard NSAIDs or paracetamol are inadequate. Unlike many NSAIDs, it has minimal anti‑inflammatory effect, but it carries a risk of rare blood disorders, which requires careful monitoring compared with other pain relievers.

Metamizol Mabo should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to extreme heat or humidity to maintain its stability.

Metamizol Mabo is administered orally. The tablet or capsule should be swallowed whole with a glass of water and taken according to the prescriber’s instructions. It is not intended for crushing, chewing, or sublingual use.

The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis. Hepatic dysfunction and renal impairment are also rare but significant adverse events that require immediate medical attention.

Metamizol Mabo should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, in patients with severe liver or kidney disease, and in those who have experienced prior agranulocytosis. It is also contraindicated in patients for whom alternative safer analgesics are appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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