Product image of Metamizol (Metamizole Sodium) supplied by GNH India

Metamizol

Active Ingredient:
Metamizole Sodium
Origin:
EU

Metamizol (Metamizole Sodium)

Metamizole sodium, the active ingredient in Metamizol, is a pyrazolone non‑opioid analgesic presented as an oral tablet for oral use. It is employed to relieve moderate to severe pain and to reduce fever in adult patients. The medication is commonly prescribed when other analgesics are insufficient.

GNH India supplies Metamizol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Farmacom Sa

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Indications & Clinical Uses

Metamizol is a non‑opioid analgesic and antipyretic used in the management of pain and fever.

  • Acute pain: provides rapid relief of moderate to severe pain.
  • Post‑operative pain: helps control discomfort after surgical procedures.
  • Fever: reduces elevated body temperature in adults.
  • Colicky abdominal pain: alleviates visceral pain associated with spasm.

How It Works

  • Metamizole sodium exerts its effect through non‑selective inhibition of cyclooxygenase enzymes, reducing prostaglandin synthesis, and by central analgesic actions that are not fully elucidated. This dual action contributes to its pain‑relieving and antipyretic properties without engaging opioid pathways.

Side Effects

Metamizole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Hypotension: occasional drop in blood pressure.
  • Skin rash: mild erythema.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Aplastic anemia: bone‑marrow failure.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Anaphylactic shock: acute allergic response.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess blood counts: monitor complete blood count before and during treatment.
  • Evaluate renal function: adjust use in patients with renal impairment.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use cautiously in elderly: increased risk of hypotension.
  • Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Metamizole can interact with several drug classes; awareness helps prevent complications.

Major Interactions (Avoid)

  • Concurrent use with other myelosuppressive agents: risk of severe blood dyscrasias.
  • Combination with sulfonamide antibiotics: increased risk of agranulocytosis.
  • Co‑administration with anticoagulants: may enhance bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Interaction with ACE inhibitors: may potentiate hypotensive effects.
  • Use with other NSAIDs: additive gastrointestinal irritation.
  • Concomitant corticosteroids: increased risk of ulceration.

Frequently Asked Questions

Metamizol is used to treat moderate to severe pain and to lower elevated body temperature. It is commonly prescribed for acute pain episodes, postoperative discomfort, and fever when other analgesics or antipyretics are insufficient.

Metamizole works by non‑selectively inhibiting cyclooxygenase enzymes, which reduces prostaglandin production, and by exerting central analgesic actions that are not fully understood. This combination provides both pain‑relieving and fever‑reducing effects.

The exact dose of Metamizol is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. Healthcare professionals tailor the regimen to achieve optimal pain control or fever reduction while monitoring safety.

Safety data for Metamizol during pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit outweighs the possible risk to the fetus or infant, and only under medical supervision.

To order Metamizol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metamizol belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct safety profile. Unlike ibuprofen or naproxen, it carries a risk of severe blood‑cell disorders, so clinicians weigh benefits against these specific risks when selecting therapy.

Metamizol tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Metamizol is supplied as oral tablets that are swallowed whole with a glass of water. It is taken by mouth as directed by a healthcare professional, typically with or without food depending on individual tolerance.

The most serious risks include agranulocytosis, aplastic anemia, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylactic shock. Patients should be monitored for signs of infection, unusual bleeding, or skin changes, and treatment should be stopped immediately if these occur.

Metamizol should be avoided in individuals with known hypersensitivity to the drug, a history of blood‑cell disorders, severe renal impairment, or those currently receiving other myelosuppressive therapies. Pregnant or breastfeeding women should use it only if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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