Product image of Metamizol Normon (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Normon

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Normon (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Normon, is a pyrazolone presented as an oral tablet for oral use. It treats pain and fever in adult patients and is prescribed when other analgesics are insufficient.
GNH India supplies Metamizol Normon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Normon, S.A.

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Indications & Clinical Uses

Metamizole sodium is used to manage pain and fever by acting on prostaglandin-mediated pathways.

  • Pain: provides analgesic relief for moderate to severe pain conditions.
  • Fever: reduces elevated body temperature in febrile states.
  • Post‑operative pain: helps control pain after surgical procedures.

How It Works

  • Metamizole sodium inhibits cyclooxygenase‑dependent prostaglandin synthesis and also modulates central pain pathways, leading to reduced peripheral inflammation and altered perception of pain signals in the central nervous system.

Side Effects

Metamizole sodium may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional emesis after dosing.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Hepatotoxicity: significant liver enzyme elevation or injury.

Precautions & Warnings

Before prescribing Metamizol Normon, clinicians should consider several safety measures.

  • Blood count monitoring: assess for agranulocytosis before and during therapy.
  • Hypersensitivity avoidance: do not use in patients with known pyrazolone allergy.
  • Renal impairment caution: adjust use in reduced kidney function.
  • Hepatic disease caution: monitor liver function tests.
  • Pregnancy and breastfeeding: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Metamizol Normon can interact with other medicines; interactions vary in severity.

Major Interactions (Avoid)

  • Myelosuppressive agents: increased risk of agranulocytosis.
  • ACE inhibitors: may enhance hypotensive effect.
  • Other NSAIDs: heightened gastrointestinal toxicity.
  • Anticoagulants: increased bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypotension.
  • CYP450 substrates: possible alteration of drug metabolism.
  • Alcohol: may increase central nervous system depression.

Frequently Asked Questions

Metamizol Normon contains metamizole sodium, a prescription‑only analgesic and antipyretic. It is employed to relieve moderate to severe pain and to lower elevated body temperature in adult patients when other treatments are insufficient or not tolerated.

Metamizole sodium works by inhibiting cyclooxygenase‑mediated prostaglandin production and by modulating central pain pathways. This dual action reduces inflammation‑driven pain signals and helps reset the body’s temperature‑regulating center, providing analgesic and antipyretic effects.

The appropriate dose of Metamizol Normon is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, weight, and renal or hepatic function. Dosage instructions are provided on the prescription label and should be followed exactly.

Safety data for metamizole sodium in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the possible risk to the fetus or infant, and only under direct medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional NSAIDs such as ibuprofen, metamizole offers potent analgesia and antipyresis with a lower risk of gastrointestinal ulceration but carries a unique risk of agranulocytosis. Choice of therapy depends on individual patient risk factors and clinical judgment.

Metamizol Normon tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the package.

The medication is supplied as oral tablets. Patients should swallow the tablet whole with a full glass of water, unless otherwise directed by a healthcare professional. It is taken by mouth as prescribed, typically with or without food.

The most serious adverse events include agranulocytosis, which can lead to severe infections, and rare but life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical attention is required if signs of infection, rash, or breathing difficulty develop.

Metamizol Normon should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, in patients with existing blood dyscrasias, severe liver or kidney impairment, and in pregnant or breastfeeding women unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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