Metamizol Pensa Pharma (Metamizole Magnesium)

• Metamizole is a pyrazolone analgesic used to manage pain and fever.
• Mild to moderate pain: Provides effective analgesia for acute or chronic pain conditions, improving patient comfort.
• Post‑operative pain: Reduces surgical site discomfort and facilitates early mobilization after procedures.
• Fever: Lowers elevated body temperature by acting on central thermoregulatory pathways.
• Colic: Alleviates visceral pain associated with gastrointestinal or biliary colic episodes.

• Metamizole inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis, and also modulates endogenous opioid pathways, contributing to its analgesic and antipyretic effects without significant opioid receptor activation.

Metamizole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Nausea or vomiting: Gastrointestinal upset occurring shortly after dosing.
• Dizziness or light‑headedness: Transient sensation of imbalance.
• Hypotension: Mild drop in blood pressure, especially with rapid administration.
• Rash or mild skin irritation: Localized erythema or itching.
• Headache: Tension‑type discomfort.
• Diarrhoea: Loose stools in some patients.

Serious or Rare Side Effects

• Agranulocytosis: Severe reduction in white blood cells, requiring immediate medical attention.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis: Life‑threatening skin reactions.
• Anaphylactic shock: Rapid onset of severe allergic response.
• Hepatic dysfunction: Elevated liver enzymes indicating liver injury.
• Renal impairment: Decreased kidney function, especially in predisposed individuals.
• Blood dyscrasias: Unusual bleeding or clotting abnormalities.

Careful assessment and monitoring are advised when using Metamizole.

• Assess renal function: Adjust use in patients with severe renal impairment.
• Monitor blood counts: Watch for early signs of agranulocytosis.
• Avoid in known hypersensitivity: Discontinue if allergic reactions occur.
• Use caution in hepatic disease: Consider liver function before initiation.
• Pregnancy and lactation: Safety not established; weigh risks and benefits.
• Store at ambient temperature: Keep in the original container, protect from moisture and direct sunlight.

Metamizole can interact with other medicines, requiring attention to potential risks.

Major Interactions (Avoid)

• Myelotoxic agents (e.g., chemotherapy): Combined use may markedly increase risk of agranulocytosis.
• Drugs lowering seizure threshold: May heighten seizure risk when used together.

Moderate Interactions (Monitor Closely)

• NSAIDs: Additive gastrointestinal irritation and bleeding risk.
• Cimetidine or other H2 blockers: May raise plasma levels of Metamizole.
• Alcohol: Can enhance central nervous system depression.
• Anticoagulants (e.g., warfarin): Potential for increased bleeding tendency.
• Diuretics: May potentiate hypotensive effects.