Product image of Metamizol +pharma (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol +pharma

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol +pharma (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol +pharma, is a pyrazolone analgesic presented as an oral formulation for oral use. It is employed to manage moderate to severe pain, high fever, and visceral colic in adult patients. The product is marketed across the European Union and is available only by prescription.

GNH India supplies Metamizol +pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and offers reliable global distribution for this prescription‑only analgesic.

Manufacturer / TM Owner

+pharma Arzneimittel Gmbh

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Indications & Clinical Uses

Metamizol +pharma is used to treat conditions involving pain and fever through inhibition of prostaglandin synthesis.

  • Moderate to severe pain: provides analgesia for acute or postoperative pain.
  • High fever: reduces elevated body temperature when other antipyretics are insufficient.
  • Visceral colic: alleviates spasm‑related abdominal pain such as renal colic.

How It Works

  • Metamizole sodium acts as a non‑selective cyclooxygenase inhibitor, decreasing synthesis of prostaglandins and other inflammatory mediators. It also modulates central pain pathways by influencing spinal and supraspinal neurotransmission, contributing to its analgesic and antipyretic effects. Additionally, the drug may affect opioid receptors indirectly, enhancing its analgesic profile.

Side Effects

Metamizole sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Skin rash: mild erythematous reaction.
  • Hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction of white blood cells.
  • Anaphylactic reaction: life‑threatening hypersensitivity.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

When prescribing Metamizol +pharma, clinicians should observe several safety measures to minimize risks.

  • Monitor blood counts: regular CBC testing is recommended due to risk of agranulocytosis.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Use caution in renal impairment: dose adjustment may be required.
  • Limit concurrent myelosuppressive therapy: increased risk of blood dyscrasias.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metamizol +pharma can interact with other medicines, influencing safety and efficacy.

Major Interactions (Avoid)

  • Concurrent use with other bone‑marrow suppressants: may potentiate agranulocytosis.
  • Combination with other NSAIDs or COX inhibitors: increased risk of gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): may enhance bleeding tendency.
  • Antihypertensive agents: additive hypotensive effect.
  • Diuretics: may affect renal clearance.

Frequently Asked Questions

Metamizol +pharma is a prescription‑only analgesic indicated for the relief of moderate to severe pain, the reduction of high fever when other antipyretics are inadequate, and the treatment of visceral colic such as renal or biliary spasm‑related abdominal pain.

Metamizole sodium exerts its effect by non‑selectively inhibiting cyclooxygenase enzymes, which lowers prostaglandin production and reduces inflammation. It also influences central pain pathways in the spinal cord and brain, providing additional analgesic and antipyretic actions.

The appropriate dose of Metamizol +pharma is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal function. Dosage regimens are individualized and should follow local prescribing guidelines.

Safety data for Metamizole sodium in pregnancy and lactation are limited. Because of potential risks such as agranulocytosis, it is generally avoided unless the benefit clearly outweighs the risk and no safer alternative is available. Consultation with a healthcare professional is essential.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional NSAIDs such as ibuprofen, Metamizol offers strong analgesic and antipyretic effects with a lower incidence of gastric irritation but carries a unique risk of severe blood dyscrasias like agranulocytosis. Choice of therapy should balance efficacy, safety profile, and patient‑specific factors.

Store Metamizol +pharma at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its stability and potency.

Metamizol +pharma is administered orally. The tablet or oral formulation should be swallowed whole with a glass of water, unless otherwise directed by a healthcare professional.

The most serious adverse events include agranulocytosis, which can lead to severe infections, and life‑threatening hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt medical attention is required if symptoms of these conditions appear.

Metamizol +pharma should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with existing blood dyscrasias, severe liver disease, or those currently receiving other bone‑marrow suppressive therapies. Use in children is generally contraindicated unless specifically approved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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