Product image of Metamizol Stada (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Stada

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Stada (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Stada, is a pyrazolone analgesic presented as an oral formulation for oral use. It is employed to relieve mild to moderate pain, reduce fever, and manage postoperative and visceral pain in adult patients. The product meets European Union pharmaceutical quality standards and is classified as prescription‑only.

GNH India supplies Metamizol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company provides regulatory support, customs clearance assistance, and reliable logistics where required.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Metamizol Stada, a pyrazolone analgesic, is used in several pain‑related and febrile conditions.

  • Mild to moderate pain: provides analgesia for everyday aches and musculoskeletal discomfort.
  • Fever: reduces elevated body temperature in acute infectious or inflammatory states.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Colic and visceral pain: alleviates spasm‑related discomfort in the gastrointestinal tract.
  • Cancer‑related pain: used as part of multimodal analgesia for tumor‑associated pain.

How It Works

  • Metamizole sodium exerts its effect by non‑selective inhibition of cyclooxygenase enzymes, which lowers prostaglandin synthesis and diminishes peripheral sensitisation. Additionally, it acts centrally by modulating pain pathways in the spinal cord and brain, contributing to its antipyretic and analgesic properties without significant anti‑inflammatory activity.

Side Effects

Metamizol Stada may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Nausea or vomiting: mild gastrointestinal upset occurring shortly after dosing.
  • Dizziness or light‑headedness: transient sensation of unsteadiness.
  • Skin rash or itching: mild dermatologic irritation.
  • Headache: occasional throbbing pain in the head region.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells, potentially leading to infection.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: life‑threatening skin reactions.
  • Anaphylaxis: rapid onset of allergic symptoms including airway compromise.
  • Hepatic or renal impairment: abnormal liver enzymes or kidney function tests.

Precautions & Warnings

Before initiating therapy with Metamizol Stada, several safety considerations should be observed.

  • Baseline blood count: obtain complete blood count to detect pre‑existing cytopenias.
  • Renal or hepatic dysfunction: adjust use or monitor closely in patients with organ impairment.
  • Hypotension risk: be cautious in individuals prone to low blood pressure.
  • Known hypersensitivity: avoid in patients with documented allergy to pyrazolones.
  • Concomitant immunosuppressants: monitor for additive bone‑marrow suppression.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizol Stada can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding due to additive anticoagulant effect.
  • Methotrexate: heightened toxicity, especially to bone marrow and liver.
  • Cyclosporine: enhanced nephrotoxic potential when combined.

Moderate Interactions (Monitor Closely)

  • NSAIDs: additive gastrointestinal irritation and ulcer risk.
  • Diuretics: possible potentiation of hypotensive effects.

Frequently Asked Questions

Metamizol Stada is indicated for relief of mild to moderate pain, reduction of fever, management of postoperative discomfort, and treatment of colic or visceral pain. It is commonly prescribed for adult patients who require an effective analgesic and antipyretic when other options are unsuitable.

Metamizole sodium works by non‑selectively inhibiting cyclooxygenase enzymes, which reduces the production of prostaglandins that mediate pain and fever. It also influences central pain pathways in the spinal cord and brain, providing additional analgesic and antipyretic effects without strong anti‑inflammatory activity.

The appropriate dose of Metamizol Stada is determined by the prescribing clinician based on the patient’s condition, age, weight, and overall health. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

The safety of Metamizol Stada in pregnancy and lactation has not been definitively established, and the pregnancy category is listed as unknown. Healthcare providers should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Metamizol Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with non‑opioid analgesics such as NSAIDs, Metamizol Stada offers effective pain relief and fever reduction with a lower risk of gastrointestinal ulceration but carries a rare risk of severe blood disorders. It is often chosen when NSAIDs are contraindicated or ineffective.

Metamizol Stada should be stored at room temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and sources of heat to maintain its stability and potency.

Metamizol Stada is administered orally. The tablet or liquid is taken by mouth with or without food, as directed by the prescribing healthcare professional. Swallow the dosage form whole unless the label specifies otherwise.

The most serious adverse reactions include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe skin reactions such as Stevens‑Johnson syndrome. Early detection through regular blood monitoring is essential to mitigate these risks.

Metamizol Stada should be avoided in individuals with a known hypersensitivity to pyrazolones or any component of the formulation, in patients with a history of severe blood dyscrasias, and in those for whom safer alternative analgesics are available. Use only under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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