Product image of Metamizol Stada (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Stada

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Stada (Metamizole Sodium Monohydrate)

Metamizole Sodium Monohydrate, the active ingredient in Metamizol Stada, is a pyrazolone presented as an oral dosage form for oral use. It treats pain and fever in adults and children as directed by a healthcare professional.

GNH India supplies Metamizol Stada as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

Metamizol Stada is a pyrazolone analgesic and antipyretic used to manage pain and fever.

  • Acute pain: provides rapid relief of moderate to severe pain.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Fever: reduces elevated body temperature associated with infectious or inflammatory conditions.

How It Works

  • Metamizole Sodium Monohydrate inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis. This reduction diminishes peripheral sensitization and also exerts central analgesic effects through modulation of spinal pain pathways, resulting in analgesia and antipyresis.

Side Effects

Metamizol Stada may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Mild skin rash or itching
  • Hypotension, especially with rapid intravenous administration
  • Transient liver enzyme elevation

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Aplastic anemia or other bone‑marrow suppression
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Anaphylactic or severe allergic reactions
  • Hepatic failure or severe hepatitis

Precautions & Warnings

Before initiating therapy with Metamizol Stada, consider the following precautions.

  • Blood count monitoring: perform baseline and periodic complete blood counts to detect early signs of agranulocytosis.
  • Renal or hepatic impairment: use with caution and adjust dosing as clinically indicated.
  • Known hypersensitivity: avoid in patients with documented allergy to metamizole or other pyrazolones.
  • Concomitant myelosuppressive drugs: monitor closely for additive bone‑marrow toxicity.
  • Medical supervision: only use under prescription and regular clinical review.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metamizol Stada can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other myelosuppressive agents: heightened risk of severe blood dyscrasias.
  • ACE inhibitors or diuretics: may potentiate hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Sulfonamide antibiotics: potential additive hypersensitivity.
  • Lithium: possible increase in lithium serum levels.
  • Antiepileptic drugs: may alter seizure threshold in susceptible individuals.

Frequently Asked Questions

Metamizol Stada contains metamizole sodium monohydrate, a pyrazolone that is prescribed to relieve moderate to severe pain and to reduce fever. It is commonly used in acute pain settings, postoperative pain management, and for febrile conditions when other antipyretics are unsuitable.

Metamizole works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production. This action reduces peripheral inflammation and also provides central analgesic effects by modulating spinal pain pathways, resulting in both pain relief and fever reduction.

The appropriate dose of Metamizol Stada is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and response to therapy. Dosing instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for metamizole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole belongs to the pyrazolone class, offering strong analgesic and antipyretic effects similar to non‑steroidal anti‑inflammatory drugs (NSAIDs) but with a different safety profile. Unlike many NSAIDs, it has a lower risk of gastrointestinal irritation but carries a rare risk of severe blood disorders such as agranulocytosis.

Metamizol Stada should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and potency.

Metamizol Stada is supplied as an oral dosage form and is taken by mouth with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water; it should not be crushed or chewed unless specifically instructed.

The most serious adverse reactions include agranulocytosis, aplastic anemia, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should be monitored for signs of infection, unexplained fever, rash, or breathing difficulties, and seek immediate medical attention if these occur.

Metamizol Stada should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, in patients with a history of severe blood dyscrasias, and in those currently receiving other myelosuppressive therapies unless closely supervised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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