Product image of Metamizol Stada (Metamizole Sodium Monohydrate) supplied by GNH India

Metamizol Stada

Active Ingredient:
Metamizole Sodium Monohydrate
Origin:
EU

Metamizol Stada (Metamizole Sodium Monohydrate)

Metamizole sodium, the active ingredient in Metamizol Stada, is a pyrazolone analgesic presented as an oral formulation for systemic use. It is employed to relieve mild to moderate pain, manage postoperative discomfort, reduce fever, and treat colic or visceral pain in adult patients.

GNH India supplies Metamizol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch, ensuring reliable supply chains across multiple regions.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Metamizole sodium is used to manage pain and fever by acting on prostaglandin‑mediated pathways.

  • Mild to moderate pain: provides analgesia to reduce discomfort in acute or chronic settings.
  • Post‑operative pain: helps control surgical pain during the recovery period.
  • Fever: lowers elevated body temperature associated with infection or inflammation.
  • Colic and visceral pain: alleviates spasm‑related discomfort in the gastrointestinal tract.

How It Works

  • Metamizole sodium inhibits cyclooxygenase (COX) enzymes, leading to decreased synthesis of prostaglandins. This reduction diminishes peripheral sensitization and central pain transmission, producing analgesic effects, while also lowering the hypothalamic set‑point for temperature regulation, resulting in antipyretic activity.

Side Effects

Adverse reactions may occur with Metamizole sodium use.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Headache
  • Mild skin rash
  • Transient hypotension
  • Gastro‑intestinal discomfort

Serious or Rare Side Effects

  • Agranulocytosis (severe drop in white blood cells)
  • Anaphylactic shock or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic dysfunction
  • Renal impairment
  • Blood dyscrasias such as thrombocytopenia

Precautions & Warnings

Before prescribing Metamizole sodium, consider the following safety measures.

  • Assess renal and hepatic function: adjust use in patients with impairment.
  • Monitor complete blood count: early detection of agranulocytosis is essential.
  • Avoid in known hypersensitivity: discontinue immediately if allergic signs appear.
  • Use with caution in the elderly: increased susceptibility to hypotension and adverse effects.
  • Pregnancy and breastfeeding: safety not established; consider alternative therapies.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metamizole sodium can interact with other medicines; awareness of key interactions helps prevent complications.

Major Interactions (Avoid)

  • Concurrent use with other myelotoxic agents: heightened risk of agranulocytosis.
  • Combination with other NSAIDs or COX inhibitors: increased gastrointestinal toxicity.
  • Co‑administration with ACE inhibitors: may exacerbate hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential enhancement of anticoagulant effect.
  • Lithium: possible increase in serum lithium concentrations.
  • Methotrexate: may raise risk of toxicity and bone marrow suppression.

Frequently Asked Questions

Metamizol Stada contains metamizole sodium, a pyrazolone analgesic indicated for the relief of mild to moderate pain, postoperative discomfort, fever, and colic or visceral pain. It is prescribed for adult patients when effective analgesia or antipyresis is required.

Metamizole sodium works by inhibiting cyclooxygenase enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels decrease peripheral pain signaling and reset the hypothalamic temperature set‑point, providing both analgesic and antipyretic effects.

The specific dose of Metamizol Stada is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Healthcare professionals follow national guidelines and adjust the regimen as needed.

Safety data for metamizole sodium during pregnancy and lactation are limited. Because potential risks cannot be ruled out, it is generally advised to avoid use in pregnant or breastfeeding women unless the benefits clearly outweigh the risks and no safer alternative is available.

To request Metamizol Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metamizole belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct safety profile. Unlike opioids, it does not cause respiratory depression, yet it carries a rare risk of agranulocytosis, which is less common with many traditional NSAIDs.

Metamizol Stada should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Metamizol Stada is administered orally. The tablet (or other oral form) should be swallowed whole with water and taken according to the prescriber’s instructions, typically with or without food as directed.

The most serious adverse events associated with metamizole sodium include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Immediate medical attention is required if signs of infection, rash, or breathing difficulty develop.

Metamizol Stada should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis or severe blood dyscrasias, and those with uncontrolled hypotension. Caution is also advised for patients with significant liver or kidney impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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